ID 2.3.1.255 DE N-terminal amino-acid N(alpha)-acetyltransferase NatA. CA (1) acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal CA N(alpha)-acetylglycyl-[protein]. CA (2) acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N-terminal CA N(alpha)-acetyl-L-alanyl-[protein]. CA (3) acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N-terminal CA N(alpha)-acetyl-L-seryl-[protein]. CA (4) acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N-terminal CA N(alpha)-acetyl-L-valyl-[protein]. CA (5) acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + CA N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]. CA (6) acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + CA N-terminal N(alpha)-acetyl-L-threonyl-[protein]. CC -!- N-terminal-acetylases (NATs) catalyze the covalent attachment of an CC acetyl moiety from acetyl-CoA to the free alpha-amino group at the CC N-terminus of a protein. CC -!- This irreversible modification neutralizes the positive charge at the CC N-terminus and makes the N-terminal residue larger and more CC hydrophobic. CC -!- The NatA complex is found in all eukaryotic organisms, CC and specifically targets N-terminal Ala, Gly, Cys, Ser, Thr, and Val CC residues, that became available after removal of the initiator CC methionine. CC -!- Formerly EC 2.3.1.88. DR Q9UTI3, ARD1_SCHPO ; P07347, ARD1_YEAST ; O61219, DAF31_CAEEL; DR Q7X9V3, GNAT2_ARATH; Q9ZV08, GNAT4_ARATH; Q9LR91, GNAT5_ARATH; DR Q8GUT5, GNAT6_ARATH; Q94AC8, GNAT7_ARATH; Q9C7G6, GNT10_ARATH; DR Q9FKI4, NAA10_ARATH; Q2KI14, NAA10_BOVIN; P41227, NAA10_HUMAN; DR Q9QY36, NAA10_MOUSE; Q9BSU3, NAA11_HUMAN; Q3UX61, NAA11_MOUSE; DR Q4V8K3, NAA11_RAT ; Q980R9, NAT_SACS2 ; Q4JBG0, NAT_SULAC ; DR Q976C3, NAT_SULTO ; I6YG32, RIMI_MYCTU ; //