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ENZYME

ENZYME entry: EC 2.3.1.256

Accepted Name
N-terminal methionine N(alpha)-acetyltransferase NatC
Reaction catalysed
  • acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]
  • acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]
  • acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]
  • acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]
  • acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]
Comment(s)
  • N-terminal-acetylases (NATs) catalyze the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein.
  • This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing.
  • The NatC complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to bulky hydrophobic residues at the second position, including Leu, Ile, Phe, Trp, and Tyr residues.
  • Formerly EC 2.3.1.88.
Cross-references
BRENDA2.3.1.256
EC2PDB2.3.1.256
ExplorEnz2.3.1.256
PRIAM enzyme-specific profiles2.3.1.256
KEGG Ligand Database for Enzyme Nomenclature2.3.1.256
IUBMB Enzyme Nomenclature2.3.1.256
IntEnz2.3.1.256
MEDLINEFind literature relating to 2.3.1.256
MetaCyc2.3.1.256
Rhea expert-curated reactions2.3.1.256
UniProtKB/Swiss-Prot
O80438, MAK3_ARATHQ147X3, NAA30_HUMANQ8CES0, NAA30_MOUSE
O74311, NAA30_SCHPOQ0IHH1, NAA30_XENLAQ03503, NAA30_YEAST

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