ID   2.3.1.257
DE   N-terminal L-serine N(alpha)-acetyltransferase NatD.
CA   (1) acetyl-CoA + N-terminal L-seryl-[histone H4] = CoA + H(+) +
CA   N-terminal N(alpha)-acetyl-L-seryl-[histone H4].
CA   (2) acetyl-CoA + N-terminal L-seryl-[histone H2A] = CoA + H(+) +
CA   N-terminal N(alpha)-acetyl-L-seryl-[histone H2A].
CC   -!- N-terminal-acetylases (NATs) catalyze the covalent attachment of an
CC       acetyl moiety from acetyl-CoA to the free alpha-amino group at the
CC       N-terminus of a protein.
CC   -!- This irreversible modification neutralizes the positive charge at the
CC       N-terminus and makes the N-terminal residue larger and more
CC       hydrophobic.
CC   -!- NatD is found in all eukaryotic organisms, and acetylates solely the
CC       serine residue at the N-terminus of histones H2A or H4.
CC   -!- Efficient recognition and acetylation by NatD requires at least the
CC       first 30 to 50 highly conserved amino acid residues of the histone N
CC       terminus.
CC   -!- Formerly EC 2.3.1.88.
DR   Q568K5, NAA40_DANRE;  Q86UY6, NAA40_HUMAN;  Q8VE10, NAA40_MOUSE;
DR   Q9USH6, NAA40_SCHPO;  Q6NUH2, NAA40_XENLA;  Q04751, NAA40_YEAST;
//