ID   2.3.1.259
DE   N-terminal methionine N(alpha)-acetyltransferase NatF.
CA   acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+)
CA   + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein].
CC   -!- N-terminal-acetylases (NATs) catalyze the covalent attachment of an
CC       acetyl moiety from acetyl-CoA to the free alpha-amino group at the
CC       N-terminus of a protein.
CC   -!- This irreversible modification neutralizes the positive charge at the
CC       N-terminus, makes the N-terminal residue larger and more hydrophobic,
CC       and prevents its removal by hydrolysis.
CC   -!- NatF is found only in higher eukaryotes, and is absent from yeast.
CC   -!- Unlike other Nat systems the enzyme is located in the Golgi
CC       apparatus.
CC   -!- It faces the cytosolic side of intracellular membranes,
CC       and specifically acetylates transmembrane proteins whose N termini
CC       face the cytosol.
CC   -!- NatF targets N-terminal L-methionine residues attached to Lys, Ser,
CC       Val, Leu, Gln, Ile, Tyr and Thr residues.
CC   -!- Formerly EC 2.3.1.88.
DR   Q17QK9, NAA60_BOVIN;  A3KPA3, NAA60_DANRE;  Q95SX8, NAA60_DROME;
DR   Q9H7X0, NAA60_HUMAN;  Q9DBU2, NAA60_MOUSE;  Q3MHC1, NAA60_RAT  ;
DR   A8E5V7, NAA60_XENTR;
//