ID   2.3.1.26
DE   sterol O-acyltransferase.
AN   cholesterol acyltransferase.
AN   sterol-ester synthase.
CA   a long-chain fatty acyl-CoA + a sterol = a sterol ester + CoA.
CC   -!- The enzyme catalyzes the formation of sterol esters from a sterol and
CC       long-chain fatty acyl-coenzyme A.
CC   -!- The enzyme from yeast, but not from mammals, prefers monounsaturated
CC       acyl-CoA.
CC   -!- In mammals the enzyme acts mainly on cholesterol and forms
CC       cholesterol esters that are stored in cytosolic droplets, which may
CC       serve to protect cells from the toxicity of free cholesterol.
CC   -!- In macrophages, the accumulation of cytosolic droplets of cholesterol
CC       esters results in the formation of 'foam cells', a hallmark of early
CC       atherosclerotic lesions.
CC   -!- In hepatocytes and enterocytes, cholesterol esters can be
CC       incorporated into apolipoprotein B-containing lipoproteins for
CC       secretion from the cell.
DR   O77760, SOAT1_CHLAE;  Q60457, SOAT1_CRIGR;  P35610, SOAT1_HUMAN;
DR   O77761, SOAT1_MACFA;  Q61263, SOAT1_MOUSE;  O70536, SOAT1_RAT  ;
DR   O77759, SOAT2_CHLAE;  O75908, SOAT2_HUMAN;  O88908, SOAT2_MOUSE;
DR   Q7TQM4, SOAT2_RAT  ;
//