ID   2.3.1.260
DE   tetracycline polyketide synthase.
CA   8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA = 18-carbamoyl-
CA   3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA.
CC   -!- The synthesis, in the bacterium Streptomyces rimosus of the
CC       tetracycline antibiotics core skeleton requires a minimal polyketide
CC       synthase (PKS) consisting of a ketosynthase (KS), a chain length
CC       factor (CLF), and an acyl-carrier protein (ACP).
CC   -!- Initiation involves an amide-containing starter unit that becomes the
CC       C-2 amide that is present in the tetracycline compounds.
CC   -!- Following the initiation, the PKS catalyzes the iterative
CC       condensation of 8 malonyl-CoA molecules to yield the polyketide
CC       backbone of tetracycline.
CC   -!- Throughout the proccess, the nascent chain is attached to the
CC       OxyC acyl-carrier protein.
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