ID   2.3.1.261
DE   (4-hydroxyphenyl)alkanoate synthase.
CA   (1) 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) +
CA   8 malonyl-CoA + 16 NADPH = 17-(4-hydroxyphenyl)heptadecanoyl-
CA   [4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+).
CA   (2) 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) +
CA   9 malonyl-CoA + 18 NADPH = 19-(4-hydroxyphenyl)nonadecanoyl-
CA   [4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+).
CC   -!- The enzyme is part of the biosynthetic pathway of phenolphthiocerol,
CC       a lipid that serves as a virulence factor of pathogenic mycobacteria.
CC   -!- It catalyzes the elongation of 4-hydroxybenzoate that is loaded on
CC       its acyl-carrier domain to form (4-hydroxyphenyl)alkanoate
CC       intermediates.
CC   -!- The enzyme adds either 8 or 9 malonyl-CoA units, resulting in
CC       formation of 17-(4-hydroxyphenyl)heptadecanoate or
CC       19-(4-hydroxyphenyl)nonadecanoate, respectively.
CC   -!- As the enzyme lacks a thioesterase domain, the product remains loaded
CC       on the acyl-carrier domain at the end of catalysis, and has to be
CC       hydrolyzed by an as-yet unknown mechanism.
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