ENZYME entry: EC 2.3.1.262
Accepted Name |
Anthraniloyl-CoA anthraniloyltransferase.
|
Reaction catalysed |
Anthraniloyl-CoA + malonyl-CoA <=> (2-aminobenzoyl)acetyl-CoA + CoA + CO(2) |
Comment(s) |
- The enzyme, characterized from the bacterium Pseudomonas aeruginosa,
participates in the synthesis of the secondary metabolites 2-heptyl-
3-hydroxy-4(1H)-quinolone and 4-hydroxy-2(1H)-quinolone.
- The enzyme transfers an anthraniloyl group from anthraniloyl-CoA to
an internal L-cysteine residue, followed by its transfer to malonyl-
CoA to produce a short-lived product that can cyclize spontaneously
to form 4-hydroxy-2(1H)-quinolone.
- However, when EC 3.1.2.32 is present, it removes the CoA moiety from
the product, forming the stable 2-aminobenzoylacetate.
|
Cross-references |
BRENDA | 2.3.1.262 |
EC2PDB | 2.3.1.262 |
ExplorEnz | 2.3.1.262 |
PRIAM enzyme-specific profiles | 2.3.1.262 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.262 |
IUBMB Enzyme Nomenclature | 2.3.1.262 |
IntEnz | 2.3.1.262 |
MEDLINE | Find literature relating to 2.3.1.262 |
MetaCyc | 2.3.1.262 |
Rhea expert-curated reactions | 2.3.1.262 |
UniProtKB/Swiss-Prot |
|
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