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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Anthraniloyl-CoA anthraniloyltransferase.
Reaction catalysed
Anthraniloyl-CoA + malonyl-CoA <=> 2-aminobenzoylacetyl-CoA + CoA + CO(2)
  • The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the synthesis of the secondary metabolites 2-heptyl- 3-hydroxy-4(1H)-quinolone and 4-hydroxy-2(1H)-quinolone.
  • The enzyme transfers an anthraniloyl group from anthraniloyl-CoA to an internal L-cysteine residue, followed by its transfer to malonyl- CoA to produce a short-lived product that can cyclize spontaneously to form 4-hydroxy-2(1H)-quinolone.
  • However, when EC is present, it removes the CoA moiety from the product, forming the stable 2-aminobenzoylacetate.
PRIAM enzyme-specific profiles2.3.1.262
KEGG Ligand Database for Enzyme Nomenclature2.3.1.262
IUBMB Enzyme Nomenclature2.3.1.262
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