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ENZYME entry: EC 2.3.1.262

Accepted Name
Anthraniloyl-CoA anthraniloyltransferase.
Reaction catalysed
Anthraniloyl-CoA + malonyl-CoA <=> (2-aminobenzoyl)acetyl-CoA + CoA + CO(2)
Comment(s)
  • The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the synthesis of the secondary metabolites 2-heptyl- 3-hydroxy-4(1H)-quinolone and 4-hydroxy-2(1H)-quinolone.
  • The enzyme transfers an anthraniloyl group from anthraniloyl-CoA to an internal L-cysteine residue, followed by its transfer to malonyl- CoA to produce a short-lived product that can cyclize spontaneously to form 4-hydroxy-2(1H)-quinolone.
  • However, when EC 3.1.2.32 is present, it removes the CoA moiety from the product, forming the stable 2-aminobenzoylacetate.
Cross-references
BRENDA2.3.1.262
EC2PDB2.3.1.262
ExplorEnz2.3.1.262
PRIAM enzyme-specific profiles2.3.1.262
KEGG Ligand Database for Enzyme Nomenclature2.3.1.262
IUBMB Enzyme Nomenclature2.3.1.262
IntEnz2.3.1.262
MEDLINEFind literature relating to 2.3.1.262
MetaCyc2.3.1.262
Rhea expert-curated reactions2.3.1.262
UniProtKB/Swiss-Prot
P20582, PQSD_PSEAE

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