ID   2.3.1.271
DE   L-glutamate-5-semialdehyde N-acetyltransferase.
CA   acetyl-CoA + L-glutamate 5-semialdehyde = CoA + H(+) + N-acetyl-L-
CA   glutamate 5-semialdehyde.
CC   -!- The enzyme, characterized from the yeast Saccharomyces cerevisiae
CC       Sigma1278b, N-acetylates L-glutamate-5-semialdehyde, an L-proline
CC       biosynthesis/utilization intermediate, into N-acetyl-L-glutamate
CC       5-semialdehyde, an intermediate of L-arginine biosynthesis, under
CC       oxidative stress conditions.
CC   -!- Its activity results in conversion of L-proline to L-arginine,
CC       and reduction in the concentration of L-glutamate 5-semialdehyde and
CC       its equilibrium partner, (S)-1-pyrroline-5-carboxylate, which has
CC       been linked to production of reactive oxygen species stress.
CC   -!- The enzyme also acts on (S)-1-acetylazetidine-2-carboxylate, a toxic
CC       L-proline analog produced by some plants, resulting in its
CC       detoxification and conferring resistance on the yeast.
DR   Q09927, ACA1_SCHPO ;  E9P8D2, MPR1_YEASX ;
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