ID   2.3.1.281
DE   coelimycin P1 polyketide synthase.
CA   6 malonyl-CoA + NADH + 5 NADPH + 12 H(+) = (2E,5S,6E,8E,10E)-5-
CA   hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + NAD(+) + 5 NADP(+) + 6 CoA +
CA   4 H2O.
CC   -!- This polyketide synthase enzyme, characterized from the bacterium
CC       Streptomyces coelicolor A3(2), catalyzes the first reaction in the
CC       biosynthesis of coelimycin P1.
CC   -!- The enzyme is made of three proteins which together comprise six
CC       modules that contain a total of 28 domains.
CC   -!- An NADH-dependent terminal reductase domain at the C-terminus of the
CC       enzyme catalyzes the reductive release of the product.
//