ID 2.3.1.281 DE coelimycin P1 polyketide synthase. CA 12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH = (2E,5S,6E,8E,10E)-5- CA hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + CA 5 NADP(+). CC -!- This polyketide synthase enzyme, characterized from the bacterium CC Streptomyces coelicolor A3(2), catalyzes the first reaction in the CC biosynthesis of coelimycin P1. CC -!- The enzyme is made of three proteins which together comprise six CC modules that contain a total of 28 domains. CC -!- An NADH-dependent terminal reductase domain at the C-terminus of the CC enzyme catalyzes the reductive release of the product. //