ID   2.3.1.287
DE   phthioceranic/hydroxyphthioceranic acid synthase.
AN   PKS2.
CA   (1) 8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-
CA   [(hydroxy)phthioceranic acid synthase] + 16 NADPH = C40-phthioceranyl-
CA   [(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O +
CA   16 NADP(+).
CA   (2) 7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-
CA   [(hydroxy)phthioceranic acid synthase] + 14 NADPH = C37-phthioceranyl-
CA   [(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O +
CA   14 NADP(+).
CC   -!- This mycobacterial polyketide enzyme produces the hepta- and octa-
CC       methylated fatty acids known as phthioceranic acids, and presumably
CC       their hydroxylated versions.
CC   -!- Formation of hepta- and octamethylated products depends on whether
CC       the enzyme incorporates seven or eight methylmalonyl-CoA extender
CC       units, respectively.
CC   -!- Formation of hydroxylated products may result from the enzyme
CC       skipping the dehydratase (DH) and enoylreductase (ER) domains during
CC       the first cycle of condensation.
DR   Q7TVK8, PHAS_MYCBO ;  A1KQG0, PHAS_MYCBP ;  A5U9F4, PHAS_MYCTA ;
DR   P9WQE8, PHAS_MYCTO ;  P9WQE9, PHAS_MYCTU ;
//