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ENZYME entry: EC 2.3.1.289

Accepted Name
Aureothin polyketide synthase system.
Alternative Name(s)
Aureothin polyketide synthase complex.
Reaction catalysed
4-nitrobenzoyl-CoA + malonyl-CoA + 4 (S)-methylmalonyl-CoA + 4 NADPH <=> demethylluteothin + 5 CO(2) + 6 CoA + 4 NADP(+) + 3 H(2)O
Comment(s)
  • This polyketide synthase, characterized from the bacterium Streptomyces thioluteus, generates the backbone of the antibiotic aureothin.
  • It is composed of 4 modules that total 18 domains and is encoded by three genes.
  • The enzyme accepts the unusual starter unit 4-nitrobenzoyl-CoA and extends it by 4 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA.
  • The first module (encoded by aurA) is used twice in an iterative fashion, so that the five Claisen condensation reactions are catalyzed by only four modules.
  • The iteration becomes possible by the transfer of the [acp]-bound polyketide intermediate back to the ketosynthase (KS) domain on the opposite polyketide synthase strand (polyketides are homodimeric).
Cross-references
BRENDA2.3.1.289
EC2PDB2.3.1.289
ExplorEnz2.3.1.289
PRIAM enzyme-specific profiles2.3.1.289
KEGG Ligand Database for Enzyme Nomenclature2.3.1.289
IUBMB Enzyme Nomenclature2.3.1.289
IntEnz2.3.1.289
MEDLINEFind literature relating to 2.3.1.289
MetaCyc2.3.1.289
Rhea expert-curated reactions2.3.1.289

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