ID 2.3.1.291 DE sphingoid base N-palmitoyltransferase. AN mammalian ceramide synthase 5. CA a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl-sphingoid base + CA CoA + H(+). CC -!- Mammals have six ceramide synthases that exhibit relatively strict CC specificity regarding the chain-length of their acyl-CoA substrates. CC -!- Ceramide synthase 5 (CERS5) is specific for palmitoyl-CoA as the acyl CC donor. CC -!- It can use multiple sphingoid bases including sphinganine, CC sphingosine, and phytosphingosine. DR Q8N5B7, CERS5_HUMAN; Q9D6K9, CERS5_MOUSE; Q6ZMG9, CERS6_HUMAN; DR Q8C172, CERS6_MOUSE; Q9LJK3, LOH2_ARATH ; //