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ENZYME entry: EC 2.3.1.294

Accepted Name
Meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II.
Alternative Name(s)
Beta-ketoacyl-acyl carrier protein synthase KasB.
Reaction catalysed
An ultra-long-chain di-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] <=> an ultra-long-chain di-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO(2) + a holo-[acyl-carrier protein]
Comment(s)
  • The enzyme is part of the fatty acid synthase (FAS) II system of mycobacteria, which extends modified products of the FAS I system, eventually forming meromycolic acids that are incorporated into mycolic acids.
  • Meromycolic acids consist of a long chain, typically 50-60 carbons, which is functionalized by different groups.Two 3-oxoacyl-(acyl carrier protein) synthases function within the FAS II system, encoded by the kasA and kasB genes.
  • The two enzymes share some sequence identity but function independently on separate sets of substrates.
  • KasB differs from KasA (EC 2.3.1.293), by preferring longer substrates (closer to the upper limit), which also contain two double bonds.
Cross-references
BRENDA2.3.1.294
EC2PDB2.3.1.294
ExplorEnz2.3.1.294
PRIAM enzyme-specific profiles2.3.1.294
KEGG Ligand Database for Enzyme Nomenclature2.3.1.294
IUBMB Enzyme Nomenclature2.3.1.294
IntEnz2.3.1.294
MEDLINEFind literature relating to 2.3.1.294
MetaCyc2.3.1.294
Rhea expert-curated reactions2.3.1.294
UniProtKB/Swiss-Prot
P63457, KASB_MYCBO;  O69473, KASB_MYCLE;  P9WQD6, KASB_MYCTO;  
P9WQD7, KASB_MYCTU;  

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