ID   2.3.1.295
DE   mycoketide-CoA synthase.
CA   a medium-chain fatty acyl-CoA + 5 (S)-methylmalonyl-CoA + 5 malonyl-CoA +
CA   22 NADPH + 32 H(+) = a mycoketide-CoA + 10 CO2 + 22 NADP(+) + 10 CoA +
CA   11 H2O.
CC   -!- The enzyme, found in mycobacteria, is involved in the synthesis of
CC       beta-D-mannosyl phosphomycoketides.
CC   -!- It is a very large polyketide synthase that contains two complete
CC       sets of FAS-like fatty acid synthase modules.
CC   -!- It binds an acyl-CoA with 5-9 carbons as a starter unit, and extends
CC       it by five rounds of alternative additions of malonyl-CoA and
CC       methylmalonyl-CoA extender units.
CC   -!- Depending on the starter unit, the enzyme forms mycoketide-CoAs of
CC       different lengths.
DR   I6XD69, PKS12_MYCTU;
//