ID   2.3.1.297
DE   very-long-chain ceramide synthase.
AN   mammalian ceramide synthase 2.
AN   sphingoid base N-very-long-chain fatty acyl-CoA transferase.
CA   a sphingoid base + a very long-chain fatty acyl-CoA = an N-(very-long-
CA   chain fatty acyl)-sphingoid base + CoA + H(+).
CC   -!- This entry describes ceramide synthase enzymes that are specific for
CC       very-long-chain fatty acyl-CoA substrates.
CC   -!- The two isoforms from yeast and the plant LOH1 and LOH3 isoforms
CC       transfer 24:0 and 26:0 acyl chains preferentially and use
CC       phytosphingosine as the preferred sphingoid base.
CC   -!- The mammalian CERS2 isoform is specific for acyl donors of 20-26
CC       carbons, which can be saturated or unsaturated.
CC   -!- The mammalian CERS3 isoform catalyzes this activity, but has a
CC       broader substrate range and also catalyzes the activity of
CC       EC 2.3.1.298.
CC   -!- Both mammalian enzymes can use multiple sphingoid bases, including
CC       sphinganine, sphingosine, and phytosphingosine.
DR   Q3ZBF8, CERS2_BOVIN;  Q96G23, CERS2_HUMAN;  Q924Z4, CERS2_MOUSE;
DR   Q8IU89, CERS3_HUMAN;  Q1A3B0, CERS3_MOUSE;  P28496, LAC1_YEAST ;
DR   P38703, LAG1_YEAST ;
//