ID   2.3.1.298
DE   ultra-long-chain ceramide synthase.
AN   mammalian ceramide synthase 3.
AN   sphingoid base N-ultra-long-chain fatty acyl-CoA transferase.
CA   a sphingoid base + an ultra-long-chain fatty acyl-CoA = an N-(ultra-long-
CA   chain-acyl)-sphingoid base + CoA + H(+).
CC   -!- Mammals have six ceramide synthases that exhibit relatively strict
CC       specificity regarding the chain-length of their acyl-CoA substrates.
CC   -!- Ceramide synthase 3 (CERS3) is the only enzyme that is active with
CC       ultra-long-chain acyl-CoA donors (C28 or longer).
CC   -!- It is active in the epidermis, where its products are incorporated
CC       into acylceramides.
CC   -!- CERS3 also accepts (2R)-2-hydroxy fatty acids and omega-hydroxy fatty
CC       acids, and can accept very-long-chain acyl-CoA substrates (see
CC       EC 2.3.1.297).
CC   -!- It can use multiple sphingoid bases including sphinganine,
CC       sphingosine, phytosphingosine, and (6R)-6-hydroxysphingosine.
DR   Q8IU89, CERS3_HUMAN;  Q1A3B0, CERS3_MOUSE;
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