ID   2.3.1.300
DE   branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase.
CA   (1) 3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = 5-methyl-3-oxohexanoyl-
CA   [ACP] + CO2 + CoA.
CA   (2) 2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] = 4-methyl-3-
CA   oxopentanoyl-[ACP] + CO2 + CoA.
CA   (3) (2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = (4S)-4-methyl-3-
CA   oxohexanoyl-[ACP] + CO2 + CoA.
CC   -!- The enzyme is responsible for initiating branched-chain fatty acid
CC       biosynthesis by the dissociated (or type II) fatty-acid biosynthesis
CC       system (FAS-II) in some bacteria, using molecules derived from
CC       degradation of the branched-chain amino acids L-leucine, L-valine,
CC       and L-isoleucine to form the starting molecules for elongation by the
CC       FAS-II system.
CC   -!- In some organisms the enzyme is also able to use acetyl-CoA, leading
CC       to production of a mix of branched-chain and straight-chain fatty
CC       acids (cf. EC 2.3.1.180).
DR   O34746, FABH1_BACSU;  O07600, FABH2_BACSU;  P0DW99, FABH_CUTAC ;
DR   C0LNR0, FABH_LISM4 ;  Q54206, FABH_STRGA ;  Q9F6D4, FABH_STRLI ;
DR   P0A3C5, FABH_STRPN ;  Q4URQ0, FABH_XANC8 ;
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