ID   2.3.1.301
DE   mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III.
AN   mycobacterial 3-oxoacyl-[acyl carrier protein] synthase III.
CA   dodecanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 +
CA   CoA.
CC   -!- The enzyme, characterized from mycobacteria, provides a link between
CC       the type I and type II fatty acid synthase systems (FAS-I and FAS-II,
CC       respectively) found in these organisms.
CC   -!- The enzyme acts on medium- and long-chain acyl-CoAs (C12-C16)
CC       produced by the FAS-I system, condensing them with malonyl-[acyl-
CC       carrier protein] (malonyl-AcpM) and forming starter molecules for the
CC       FAS-II system, which elongates them into meromycolic acids.
CC   -!- The enzyme has no activity with short-chain acyl-CoAs (e.g. acetyl-
CC       CoA), which are used by EC 2.3.1.180, or branched-chain acyl-CoAs,
CC       which are used by EC 2.3.1.300.
DR   A0QLF3, FABH_MYCA1 ;  P0A575, FABH_MYCBO ;  A1KG10, FABH_MYCBP ;
DR   C1AKL3, FABH_MYCBT ;  B2HRM4, FABH_MYCMM ;  Q73SP5, FABH_MYCPA ;
DR   A5TZR3, FABH_MYCTA ;  P9WNG2, FABH_MYCTO ;  P9WNG3, FABH_MYCTU ;
DR   A0PLS8, FABH_MYCUA ;
//