ID 2.3.1.309 DE [beta-tubulin]-L-lysine N-acetyltransferase. CA acetyl-CoA + L-lysyl-[beta-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl- CA [beta-tubulin]. CC -!- The enzyme acetylates L-lysine at position 252 of beta-tubulin, which CC is located at the interface of alpha/beta-tubulin heterodimers and CC interacts with the phosphate group of the alpha-tubulin-bound GTP. CC -!- The acetylation is thought to attenuate tubulin incorporation into CC microtubules. CC -!- The enzyme catalyzing this activity (NAA50) also catalyzes the CC acetylation of certain N-terminal methionyl residues. That activity CC is classified as EC 2.3.1.258. cf. EC 2.3.1.108. //