ID 2.3.1.313 DE NAD-dependent lipoamidase. CA H2O + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NAD(+) = 2''-O-lipoyl-ADP-D- CA ribose + L-lysyl-[protein] + nicotinamide. CC -!- The enzyme, a member of the sirtuin family, removes the lipoyl group CC from the dihydrolipoamide acyltransferase (E2) component of 2-oxo CC acid dehydrogenase complexes such as EC 1.2.1.104. CC -!- The enzyme often has additional activities and can remove other CC modifications of lysine residues such as acetyl and biotinyl groups. CC cf. EC 3.5.1.138. //