ID   2.3.1.329
DE   isonitrile lipopeptide synthase.
CA   L-lysyl-[peptidyl-carrier protein] + 2 (3R)-3-isocyanylbutanoyl-[ACP] +
CA   2 NADPH = (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + holo-
CA   [peptidyl-carrier protein] + 2 holo-[ACP] + 2 NADP(+).
CC   -!- The enzyme, found in some actinobacterial species, is a non-ribosomal
CC       peptide synthase (NRPS).
CC   -!- Adenylation and thiolation domains of the enzyme activate a lysine
CC       residue and load it on the enzyme (this activity is described
CC       separately as EC 6.2.1.77).
CC   -!- A condensation domain catalyzes the condensation of two isonitrile-
CC       containing moieties to both amino groups of the lysine, a rare
CC       activity in non-ribosomal peptide biosynthesis.
CC   -!- A reductase domain catalyzes a four-electron reduction, releasing the
CC       product from the NRPS with a terminal alcohol group.
DR   P0DX16, INLPA_STRC4;
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