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ENZYME

ENZYME entry: EC 2.3.1.330

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.330
Accepted Name
D-xylulose 5-phosphate:acyl-carrier protein glycolyltransferase system
Reaction catalysed
N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] + D-xylulose 5-phosphate + holo-[ACP] = glycoloyl-[ACP] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] + D-glyceraldehyde 3-phosphate
Comment(s)
  • This enzyme system produces glycolyl-[acyl-carrier protein] units that can be used by non-ribosomal peptide synthases.
  • It catalyzes a transketolase-like reaction on ketose phosphates derived from primary metabolism and transfers the resulting glycolyl moiety to a dedicated acyl-carrier protein.
  • During the reaction cycle the glycolyl moiety is transferred first to a thiamine diphosphate cofactor, then to a lipoyl cofactor, and eventually to the acyl-carrier protein.
  • While D-xylulose 5-phosphate is the best substrate, the enzyme can also accept D-fructose 6-phosphate and D-sedheptulose 7-phosphate.
  • During the reaction the lipoyl cofactor is reduced to dihydrolipoyl, which must be oxidized back to lipoyl by an unknown enzyme.
Cross-references
Rhea expert-curated reactions2.3.1.330
ExplorEnz2.3.1.330
IUBMB Enzyme Nomenclature2.3.1.330
BRENDA2.3.1.330
MetaCyc2.3.1.330
KEGG Ligand Database for Enzyme Nomenclature2.3.1.330
EC2PDB2.3.1.330
MEDLINEFind literature relating to 2.3.1.330

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-