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ENZYME

ENZYME entry: EC 2.3.1.47

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.47
Accepted Name
8-amino-7-oxononanoate synthase
Alternative Name(s)
7-KAP synthetase
7-keto-8-aminopelargonic acid synthetase
8-amino-7-ketopelargonate synthase
AONS
Reaction catalysed
6-carboxyhexanoyl-[ACP] + L-alanine + H(+) = (8S)-8-amino-7-oxononanoate + holo-[ACP] + CO2
Comment(s)
  • The enzyme catalyzes the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis.
  • Pimeloyl-CoA can be used with lower efficiency.
Cross-references
BRENDA2.3.1.47
EC2PDB2.3.1.47
ExplorEnz2.3.1.47
KEGG Ligand Database for Enzyme Nomenclature2.3.1.47
IUBMB Enzyme Nomenclature2.3.1.47
MEDLINEFind literature relating to 2.3.1.47
MetaCyc2.3.1.47
Rhea expert-curated reactions2.3.1.47
UniProtKB/Swiss-Prot
Q5SHZ8, BIKB_THET8O31777, BIOF1_BACSUA7Z4X1, BIOF1_BACVZ
P9WQ86, BIOF1_MYCTOP9WQ87, BIOF1_MYCTUQ12F38, BIOF1_POLSJ
P53556, BIOF2_BACSUA7Z5B4, BIOF2_BACVZP9WQ84, BIOF2_MYCTO
P9WQ85, BIOF2_MYCTUQ12D74, BIOF2_POLSJB0C205, BIOF_ACAM1
A3DBD5, BIOF_ACET2A5FZN8, BIOF_ACICJB7J3Y7, BIOF_ACIF2
B5ELF7, BIOF_ACIF5A0KIC7, BIOF_AERHHA4SPR6, BIOF_AERS4
Q0VMD1, BIOF_ALCBSQ5DZH9, BIOF_ALIF1B5EUP9, BIOF_ALIFM
B6ESC6, BIOF_ALISLQ0A5W2, BIOF_ALKEHA6TU88, BIOF_ALKMQ
A8MEX7, BIOF_ALKOOB8J637, BIOF_ANAD2Q2IF62, BIOF_ANADE
A7HG96, BIOF_ANADFB4UCB1, BIOF_ANASKB7GHW7, BIOF_ANOFW
O66875, BIOF_AQUAEQ8GW43, BIOF_ARATHQ5NZF5, BIOF_AROAE
A1K6Q1, BIOF_AZOSBA0RIB9, BIOF_BACAHQ81MB0, BIOF_BACAN
B7JLX2, BIOF_BACC0Q731H9, BIOF_BACC1B7IWN1, BIOF_BACC2
B7HAZ0, BIOF_BACC4B7HNN4, BIOF_BACC7A7GSE1, BIOF_BACCN
B9IWY0, BIOF_BACCQQ818X0, BIOF_BACCRQ635G4, BIOF_BACCZ
Q6HE48, BIOF_BACHKQ65ML1, BIOF_BACLDA9VG56, BIOF_BACMK
Q8KZM9, BIOF_BACNAA8FDG9, BIOF_BACP2B2IH50, BIOF_BEII9
Q7WH76, BIOF_BORBRQ7W9I4, BIOF_BORPAA9HVE9, BIOF_BORPD
Q7VWP1, BIOF_BORPEQ89AK6, BIOF_BUCBPB1YNS0, BIOF_BURA4
A0KB03, BIOF_BURCHB4E9L6, BIOF_BURCJQ0BBD6, BIOF_BURCM
Q39CE6, BIOF_BURL3A9AE46, BIOF_BURM1A3MNG3, BIOF_BURM7
A2S7R1, BIOF_BURM9Q62MX1, BIOF_BURMAA1V819, BIOF_BURMS
B1JZD9, BIOF_BURO0Q1BT36, BIOF_BURO1A3NQS3, BIOF_BURP0
Q3JWR6, BIOF_BURP1A3N522, BIOF_BURP6Q63Y23, BIOF_BURPS
Q2T1Q2, BIOF_BURTAA4JIB5, BIOF_BURVGB0SZS9, BIOF_CAUSK
Q9A7Z1, BIOF_CAUVCB8GVE2, BIOF_CAUVNB3PI88, BIOF_CELJU
B3QLR6, BIOF_CHLP8Q1QYD6, BIOF_CHRSDQ7NPW2, BIOF_CHRVO
B5EEV8, BIOF_CITBBA8AJ11, BIOF_CITK8B5Y9Z4, BIOF_COPPD
A7MJ02, BIOF_CROS8Q1LS75, BIOF_CUPMCQ0KF88, BIOF_CUPNH
Q477A3, BIOF_CUPPJB2AG98, BIOF_CUPTRB8HTV6, BIOF_CYAP4
Q47C04, BIOF_DECARA9BV10, BIOF_DELASB1I4F9, BIOF_DESAP
B8J3V0, BIOF_DESDAA8ZUS7, BIOF_DESOHA7ZJI5, BIOF_ECO24
B7ULX3, BIOF_ECO27B7MGN4, BIOF_ECO45B7LC58, BIOF_ECO55
Q8X823, BIOF_ECO57B5YRL5, BIOF_ECO5EB7NNK6, BIOF_ECO7I
B7MQM9, BIOF_ECO81B7M748, BIOF_ECO8AB1X7A6, BIOF_ECODH
A7ZY32, BIOF_ECOHSA1A918, BIOF_ECOK1Q0TJS2, BIOF_ECOL5
Q8FJQ2, BIOF_ECOL6B1IXJ2, BIOF_ECOLCP12998, BIOF_ECOLI
B7NA75, BIOF_ECOLUB6I7T0, BIOF_ECOSEB1LM67, BIOF_ECOSM
Q1REF4, BIOF_ECOUTA4XZR8, BIOF_ECTM1C8V1D1, BIOF_EMENI
A4W8B8, BIOF_ENT38B2VBT8, BIOF_ERWT9B7LJY7, BIOF_ESCF3
B1YMC6, BIOF_EXIS2A7HMM1, BIOF_FERNBB9M8U3, BIOF_GEODF
Q5KY23, BIOF_GEOKAQ39XE0, BIOF_GEOMGQ749W3, BIOF_GEOSL
A5G6I9, BIOF_GEOURB8F713, BIOF_GLAP5B7KD70, BIOF_GLOC7
Q7NNL4, BIOF_GLOVIA9HJ57, BIOF_GLUDAQ0BUV6, BIOF_GRABC
Q7VL09, BIOF_HAEDUQ4QKR3, BIOF_HAEI8A5UCE4, BIOF_HAEIE
A5UJ44, BIOF_HAEIGP44422, BIOF_HAEINQ2SBD5, BIOF_HAHCH
Q9K625, BIOF_HALH5A1WVM6, BIOF_HALHLQ9ZLN3, BIOF_HELPJ
O25320, BIOF_HELPYA4G5N9, BIOF_HERARQ31E54, BIOF_HYDCU
A6SU64, BIOF_JANMAB5XZ74, BIOF_KLEP3A6T6L6, BIOF_KLEP7
B1Y500, BIOF_LEPCPP22806, BIOF_LYSSHA0L3L7, BIOF_MAGMM
Q0APZ9, BIOF_MARMMA6W0Y0, BIOF_MARMSA1U4B1, BIOF_MARN8
A6UWX3, BIOF_META3B7L0L2, BIOF_METC4Q609V1, BIOF_METCA
A9W106, BIOF_METEPQ1GZA7, BIOF_METFKQ58694, BIOF_METJA
B8IBW2, BIOF_METNOB1Z7Y8, BIOF_METPBA2SD53, BIOF_METPP
B1LYP9, BIOF_METRJB0UKC8, BIOF_METS4B8ERL9, BIOF_METSB
A6UQL9, BIOF_METVSB0JQZ0, BIOF_MICANA0QHJ9, BIOF_MYCA1
P0A4X5, BIOF_MYCBOA1KJ00, BIOF_MYCBPA4T9L3, BIOF_MYCGI
B8ZR84, BIOF_MYCLBP45487, BIOF_MYCLEB2HQ90, BIOF_MYCMM
Q740R7, BIOF_MYCPAA0QX65, BIOF_MYCS2A3Q146, BIOF_MYCSJ
A1UHM3, BIOF_MYCSKQ1B7F0, BIOF_MYCSSA5U2S6, BIOF_MYCTA
A5WMQ5, BIOF_MYCTFA0PP02, BIOF_MYCUAA1T8U6, BIOF_MYCVP
Q1DCV8, BIOF_MYXXDQ5F6R6, BIOF_NEIG1B4RP93, BIOF_NEIG2
A9M251, BIOF_NEIM0A1ITK1, BIOF_NEIMAQ9K0U0, BIOF_NEIMB
A1KVF6, BIOF_NEIMFQ0AE73, BIOF_NITECQ81ZZ4, BIOF_NITEU
Q2Y9Y8, BIOF_NITMUQ3J9D6, BIOF_NITOCB2J1W1, BIOF_NOSP7
Q8YZT3, BIOF_NOSS1A1TTV0, BIOF_PARC0A7HP29, BIOF_PARL1
Q2W3L2, BIOF_PARM1B2JKH6, BIOF_PARP8B2SWS7, BIOF_PARPJ
Q146K3, BIOF_PARXLQ9CJU0, BIOF_PASMUQ6D3C0, BIOF_PECAS
A1AQT1, BIOF_PELPDA9BGL0, BIOF_PETMOB4RFX5, BIOF_PHEZH
Q7N6Q6, BIOF_PHOLLQ6LPR3, BIOF_PHOPRB1XL23, BIOF_PICP2
A1VUJ6, BIOF_POLNAB4ESU4, BIOF_PROMHQ48CS2, BIOF_PSE14
B7V486, BIOF_PSEA8Q02TR5, BIOF_PSEABQ9I617, BIOF_PSEAE
Q1I3N7, BIOF_PSEE4Q4K4T3, BIOF_PSEF5A5VXF2, BIOF_PSEP1
A6UYW1, BIOF_PSEP7Q3K5P2, BIOF_PSEPFB0KJ54, BIOF_PSEPG
Q88QX1, BIOF_PSEPKB1JE54, BIOF_PSEPWQ88A97, BIOF_PSESM
Q4ZMA9, BIOF_PSEU2Q47829, BIOF_PSEVUQ8XZC3, BIOF_RALN1
B2UBJ3, BIOF_RALPJB7K0L9, BIOF_RIPO1Q21FY4, BIOF_SACD2
B5F073, BIOF_SALA4A9MJE5, BIOF_SALARQ57RG2, BIOF_SALCH
B5FP62, BIOF_SALDCB5QX66, BIOF_SALEPB5R762, BIOF_SALG2
B4TC49, BIOF_SALHSB4SZJ8, BIOF_SALNSQ5PG49, BIOF_SALPA
A9MTI7, BIOF_SALPBC0PWY3, BIOF_SALPCB5BC30, BIOF_SALPK
B4TQU0, BIOF_SALSVQ8Z892, BIOF_SALTIQ8ZQQ7, BIOF_SALTY
P36570, BIOF_SERMAA8GBC6, BIOF_SERP5B2TVF4, BIOF_SHIB3
Q324B6, BIOF_SHIBSQ32I45, BIOF_SHIDSQ0T6I4, BIOF_SHIF8
Q83S45, BIOF_SHIFLQ3Z408, BIOF_SHISSQ2NUJ6, BIOF_SODGM
B4SM82, BIOF_STRM5B2FLM5, BIOF_STRMKA4VR87, BIOF_STUS1
Q67N86, BIOF_SYMTHQ3A3Z8, BIOF_SYNC1P74770, BIOF_SYNY3
B7ID58, BIOF_THEABA6LMP4, BIOF_THEM4B0KC20, BIOF_THEP3
B0K590, BIOF_THEPXQ8DJ97, BIOF_THEVBB5YFU5, BIOF_THEYD
Q3SLX9, BIOF_THIDAB8GTH6, BIOF_THISHQ73KM3, BIOF_TREDE
Q119K2, BIOF_TRIEIB3EAE0, BIOF_TRIL1Q3M9A4, BIOF_TRIV2
B7VH15, BIOF_VIBA3A7MX30, BIOF_VIBC1Q9KSZ3, BIOF_VIBCH
Q87QN5, BIOF_VIBPAQ8D8N0, BIOF_VIBVUQ7MLU9, BIOF_VIBVY
Q8PQD8, BIOF_XANACQ4UZN9, BIOF_XANC8B0RMR1, BIOF_XANCB
Q8PDF1, BIOF_XANCPQ3BYN0, BIOF_XANE5Q2P8F2, BIOF_XANOM
B2SS66, BIOF_XANOPQ5H5R0, BIOF_XANORB2I9H7, BIOF_XYLF2
Q9PDM2, BIOF_XYLFAB0U6J0, BIOF_XYLFMQ87DT2, BIOF_XYLFT
A1JS67, BIOF_YERE8A7FKM8, BIOF_YERP3Q1C946, BIOF_YERPA
B2K8T1, BIOF_YERPBQ7CH66, BIOF_YERPEA9R3C9, BIOF_YERPG
Q1CFQ4, BIOF_YERPNA4TNQ5, BIOF_YERPPQ66D66, BIOF_YERPS
B1JSS3, BIOF_YERPYC4LK80, BIOWF_CORK4Q6A6M4, BIOWF_CUTAK
D4H9Y2, BIOWF_CUTAS

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-