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ENZYME

ENZYME entry: EC 2.3.1.74

Accepted Name
chalcone synthase
Alternative Name(s)
6'-deoxychalcone synthase
flavonone synthase
naringenin-chalcone synthase
Reaction catalysed
4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA
Comment(s)
  • The enzyme catalyzes the first committed step in the biosynthesis of flavonoids.
  • It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
Cross-references
BRENDA2.3.1.74
EC2PDB2.3.1.74
ExplorEnz2.3.1.74
PRIAM enzyme-specific profiles2.3.1.74
KEGG Ligand Database for Enzyme Nomenclature2.3.1.74
IUBMB Enzyme Nomenclature2.3.1.74
IntEnz2.3.1.74
MEDLINEFind literature relating to 2.3.1.74
MetaCyc2.3.1.74
Rhea expert-curated reactions2.3.1.74
UniProtKB/Swiss-Prot
P54157, BCSA_BACSUP48386, CHS1_CAMSIQ9ZRR8, CHS1_CASGL
Q9SML4, CHS1_CICARQ9XJ58, CHS1_CITSIQ9ZS41, CHS1_DAUCA
P48390, CHS1_GERHYP26018, CHS1_HORVUQ9MB33, CHS1_IPOBA
P24824, CHS1_MAIZEP30073, CHS1_MEDSAA2ZEX7, CHS1_ORYSI
Q2R3A1, CHS1_ORYSJQ01286, CHS1_PEAQ9FSB9, CHS1_RUTGR
P53414, CHS1_SECCEP13416, CHS1_SINALP23418, CHS1_SOLLC
Q9XGX2, CHS1_SORBIP24826, CHS1_SOYBNP51083, CHS1_TRISU
P48387, CHS2_CAMSIQ9XJ57, CHS2_CITSIQ9ZS40, CHS2_DAUCA
Q96562, CHS2_HORVUQ9MB41, CHS2_IPOBAP24825, CHS2_MAIZE
P30074, CHS2_MEDSAQ8H4L3, CHS2_ORYSJQ01287, CHS2_PEA
Q9FSB8, CHS2_RUTGRP53415, CHS2_SECCEP23419, CHS2_SOLLC
Q43188, CHS2_SOLTUQ9SBL7, CHS2_SORBIP17957, CHS2_SOYBN
P51084, CHS2_TRISUO23729, CHS3_BROFIP48388, CHS3_CAMSI
P48392, CHS3_GERHYQ9MB40, CHS3_IPOBAP51077, CHS3_MEDSA
O23883, CHS3_PEAQ9FSB7, CHS3_RUTGRP13417, CHS3_SINAL
Q9SBL6, CHS3_SORBIP19168, CHS3_SOYBNP51085, CHS3_TRISU
O23730, CHS4_BROFIQ9MB39, CHS4_IPOBAP30075, CHS4_MEDSA
O23882, CHS4_PEAQ9SBL5, CHS4_SORBIP51086, CHS4_TRISU
P51078, CHS5_MEDSAO23884, CHS5_PEAQ9SBL4, CHS5_SORBI
P48406, CHS5_SOYBNP51087, CHS5_TRISUQ9MB38, CHS6_IPOBA
P51079, CHS6_MEDSAQ01288, CHS6_PEAQ9SBL3, CHS6_SORBI
P30080, CHS6_SOYBNP51088, CHS6_TRISUQ9MB37, CHS7_IPOBA
P51080, CHS7_MEDSAQ9M5M0, CHS7_PICMAQ9XGX1, CHS7_SORBI
P30081, CHS7_SOYBNO23731, CHS8_BROFIQ9MB36, CHS8_IPOBA
P30076, CHS8_MEDSAQ9SB26, CHS9_DAUCAP30077, CHS9_MEDSA
P48393, CHSA_IPOCOP48395, CHSA_IPONIP48400, CHSA_IPOPL
P48397, CHSA_IPOPUP48401, CHSA_IPOTFP48403, CHSA_IPOTR
P51081, CHSA_PEAP08894, CHSA_PETHYQ41436, CHSA_SOLTU
P48394, CHSB_IPOCOP48396, CHSB_IPONIP48398, CHSB_IPOPU
P48402, CHSB_IPOTFP48404, CHSB_IPOTRP51082, CHSB_PEA
P22924, CHSB_PETHYQ43163, CHSB_SOLTUP48399, CHSC_IPOPU
O22045, CHSD_IPONIP22925, CHSD_PETHYO22046, CHSE_IPONI
O22047, CHSE_IPOPUP22926, CHSF_PETHYP22927, CHSG_PETHY
Q9FEY5, CHSH1_HUMLUA0AMG7, CHSH2_HUMLUA0AMG8, CHSH3_HUMLU
A0AMG9, CHSH4_HUMLUP22928, CHSJ_PETHYP06515, CHSY_ANTMA
Q9SEP4, CHSY_ARAALP13114, CHSY_ARATHP51075, CHSY_BETPN
P48385, CHSY_CALCHQ9SEP2, CHSY_CARANQ9ZRS4, CHSY_CATRO
O04220, CHSY_CHRAEP48389, CHSY_DIACAQ9LKP7, CHSY_DIAMO
Q9MBB1, CHSY_EQUARP51076, CHSY_FRAANO82144, CHSY_HYDMC
Q9FUB7, CHSY_HYPANP30078, CHSY_MALDOP17818, CHSY_MATIN
O22586, CHSY_ONOVIQ9ZU06, CHSY_PERAEO04111, CHSY_PERFR
P16107, CHSY_PETCRP49440, CHSY_PHAVUO65872, CHSY_PINST
P30079, CHSY_PINSYP23569, CHSY_PUEMLO22652, CHSY_RAPSA
P51089, CHSY_VIGUNP51090, CHSY_VITVIQ8RVK9, CHS_CANSA
Q55E72, PKS1_DICDIQ9AU11, PKS1_RUBIDQ9AU09, PKS3_RUBID
B0LDU5, PKS4_RUBIDB0LDU6, PKS5_RUBIDQ54FI3, STLB_DICDI
O80400, VPS_HUMLU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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