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ENZYME entry: EC 2.3.1.82

Accepted Name
aminoglycoside 6'-N-acetyltransferase
Alternative Name(s)
6'-aminoglycoside-N-acetyltransferase
AAC(6')
aminoglycoside N(6')-acetyltransferase
kanamycin 6'-N-acetyltransferase
Reaction catalysed
acetyl-CoA + kanamycin B <=> CoA + H(+) + N(6')-acetylkanamycin B
Comment(s)
  • The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C1a, gentamicin C2, sisomicin and tobramycin are substrates.
  • The antibiotic paromomycin is not a substrate.
  • The 6-amino group of the purpurosamine ring is acetylated.
  • Formerly EC 2.3.1.55.
Cross-references
BRENDA2.3.1.82
EC2PDB2.3.1.82
ExplorEnz2.3.1.82
PRIAM enzyme-specific profiles2.3.1.82
KEGG Ligand Database for Enzyme Nomenclature2.3.1.82
IUBMB Enzyme Nomenclature2.3.1.82
IntEnz2.3.1.82
MEDLINEFind literature relating to 2.3.1.82
MetaCyc2.3.1.82
Rhea expert-curated reactions2.3.1.82
UniProtKB/Swiss-Prot
Q54441, AAC6C_SERMAQ43899, AAC6_ACIBAQ44245, AAC6_ACIG1
Q44057, AAC6_ACIHAP10051, AAC6_CITKOP50858, AAC6_KLEAE
P19650, AAC6_KLEPNQ15BH7, AAC6_MORMOQ9R381, AAC6_SALEN
Q8ZPB6, AAC6_SALTYP20092, AAC6_SERMAQ9RBW7, AAC6_STEMA

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