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ENZYME entry: EC 2.3.1.87

Accepted Name
aralkylamine N-acetyltransferase.
Alternative Name(s)
AANAT.
arylalkylamine N-acetyltransferase.
melatonin rhythm enzyme.
serotonin acetylase.
serotonin acetyltransferase.
serotonin N-acetyltransferase.
Reaction catalysed
2-arylethylamine + acetyl-CoA <=> CoA + H(+) + N-acetyl-2-arylethylamine
Comment(s)
  • Narrow specificity toward 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine.
  • This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4).
  • Differs from EC 2.3.1.5.
Cross-references
BRENDA2.3.1.87
EC2PDB2.3.1.87
ExplorEnz2.3.1.87
PRIAM enzyme-specific profiles2.3.1.87
KEGG Ligand Database for Enzyme Nomenclature2.3.1.87
IUBMB Enzyme Nomenclature2.3.1.87
IntEnz2.3.1.87
MEDLINEFind literature relating to 2.3.1.87
MetaCyc2.3.1.87
Rhea expert-curated reactions2.3.1.87
UniProtKB/Swiss-Prot
Q9VMG0, DNAT2_DROME;  Q94521, DNAT_DROME;  A2Y5T7, SNAT1_ORYSI;  
Q5KQI6, SNAT1_ORYSJ;  Q6Z1Y6, SNAT2_ORYSJ;  O02785, SNAT_BOVIN;  
P79774, SNAT_CHICK;  Q16613, SNAT_HUMAN;  O97756, SNAT_MACMU;  
Q9R0A9, SNAT_MESAU;  O88816, SNAT_MOUSE;  Q5IS55, SNAT_PANTR;  
Q64666, SNAT_RAT;  Q29495, SNAT_SHEEP;  

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