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ENZYME

ENZYME entry: EC 2.3.1.87

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.87
Accepted Name
aralkylamine N-acetyltransferase
Alternative Name(s)
AANAT
arylalkylamine N-acetyltransferase
melatonin rhythm enzyme
serotonin acetylase
serotonin acetyltransferase
serotonin N-acetyltransferase
Reaction catalysed
a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+)
Comment(s)
  • Narrow specificity toward 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine.
  • This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4).
  • Differs from EC 2.3.1.5.
Cross-references
BRENDA2.3.1.87
EC2PDB2.3.1.87
ExplorEnz2.3.1.87
KEGG Ligand Database for Enzyme Nomenclature2.3.1.87
IUBMB Enzyme Nomenclature2.3.1.87
MEDLINEFind literature relating to 2.3.1.87
MetaCyc2.3.1.87
Rhea expert-curated reactions2.3.1.87
UniProtKB/Swiss-Prot
Q9VMG0, DNAT2_DROMEQ94521, DNAT_DROMEQ9C666, GNAT1_ARATH
Q7X9V3, GNAT2_ARATHQ04170, IAT4_YEASTA2Y5T7, SNAT1_ORYSI
Q5KQI6, SNAT1_ORYSJQ6Z1Y6, SNAT2_ORYSJO02785, SNAT_BOVIN
P79774, SNAT_CHICKQ16613, SNAT_HUMANO97756, SNAT_MACMU
Q9R0A9, SNAT_MESAUO88816, SNAT_MOUSEQ5IS55, SNAT_PANTR
Q64666, SNAT_RATQ29495, SNAT_SHEEP

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-