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ENZYME

ENZYME entry: EC 2.3.1.94

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.94
Accepted Name
6-deoxyerythronolide-B synthase
Alternative Name(s)
6-deoxyerythronolide B synthase
DEBS
deoxyerythronolide B synthase
erythronolide-condensing enzyme
erythronolide synthase
Reaction catalysed
6 (S)-methylmalonyl-CoA + propanoyl-CoA + 6 NADPH + 12 H(+) = 6-deoxyerythronolide B + 6 CO2 + 6 NADP(+) + 7 CoA + H2O
Comment(s)
  • The product, 6-deoxyerythronolide B, contains a 14-membered lactone ring and is an intermediate in the biosynthesis of erythromycin antibiotics.
  • Biosynthesis of 6-deoxyerythronolide B requires 28 active sites that are precisely arranged along three large polypeptides, denoted DEBS1, -2 and -3.
  • The polyketide product is synthesized by the processive action of a loading didomain, six extension modules and a terminal thioesterase domain.
  • Each extension module contains a minimum of a ketosynthase (KS), an acyltransferase (AT) and an acyl-carrier protein (ACP).
  • The KS domain both accepts the growing polyketide chain from the previous module and catalyzes the subsequent decarboxylative condensation between this substrate and an ACP-bound methylmalonyl extender unit, introduce by the AT domain.
  • This combined effort gives rise to a new polyketide intermediate that has been extended by two carbon atoms.
Cross-references
BRENDA2.3.1.94
EC2PDB2.3.1.94
ExplorEnz2.3.1.94
KEGG Ligand Database for Enzyme Nomenclature2.3.1.94
IUBMB Enzyme Nomenclature2.3.1.94
MEDLINEFind literature relating to 2.3.1.94
MetaCyc2.3.1.94
Rhea expert-curated reactions2.3.1.94
UniProtKB/Swiss-Prot
Q03131, ERYA1_SACERQ03132, ERYA2_SACERQ03133, ERYA3_SACER

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