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ENZYME entry: EC 2.3.1.97

Accepted Name
Glycylpeptide N-tetradecanoyltransferase.
Alternative Name(s)
Peptide N-myristoyltransferase.
Peptide N-tetradecanoyltransferase.
Reaction catalysed
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] <=> CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Comment(s)
  • The enzyme catalyzes the transfer of myristic acid from myristoyl-CoA to the amino group of the N-terminal glycine residue in a variety of eukaryotic proteins.
  • It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the enzyme prior to the binding of the peptide substrate, and CoA release precedes the release of the myristoylated peptide.
  • The enzyme from yeast is profoundly affected by amino acids further from the N-terminus, and is particularly stimulated by a serine residue at position 5.
Cross-references
PROSITEPDOC00752
BRENDA2.3.1.97
EC2PDB2.3.1.97
ExplorEnz2.3.1.97
PRIAM enzyme-specific profiles2.3.1.97
KEGG Ligand Database for Enzyme Nomenclature2.3.1.97
IUBMB Enzyme Nomenclature2.3.1.97
IntEnz2.3.1.97
MEDLINEFind literature relating to 2.3.1.97
MetaCyc2.3.1.97
UniProtKB/Swiss-Prot
Q9LTR9, NMT1_ARATH;  P31717, NMT1_BOVIN;  P30419, NMT1_HUMAN;  
O70310, NMT1_MOUSE;  Q5RAF3, NMT1_PONAB;  Q8K1Q0, NMT1_RAT;  
Q94L32, NMT2_ARATH;  Q9N181, NMT2_BOVIN;  A7YT82, NMT2_DANRE;  
O60551, NMT2_HUMAN;  O70311, NMT2_MOUSE;  P34763, NMT_AJECA;  
Q9EMI7, NMT_AMEPV;  Q75EK2, NMT_ASHGO;  Q9UVX3, NMT_ASPFU;  
P46548, NMT_CAEEL;  P30418, NMT_CANAL;  O74234, NMT_CANGA;  
P0CP21, NMT_CRYNB;  P34809, NMT_CRYNE;  P0CP20, NMT_CRYNJ;  
Q6BJF4, NMT_DEBHA;  Q553B6, NMT_DICDI;  O61613, NMT_DROME;  
Q8TFN1, NMT_EMENI;  Q4I061, NMT_GIBZE;  Q6CMK4, NMT_KLULA;  
Q5UR64, NMT_MIMIV;  Q9YW20, NMT_MSEPV;  Q7S3C8, NMT_NEUCR;  
Q8ILW6, NMT_PLAF7;  O43010, NMT_SCHPO;  Q4PB56, NMT_USTMA;  
Q6C7G2, NMT_YARLI;  P14743, NMT_YEAST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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