A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.3.1.97
| Accepted Name |
|---|
| Glycylpeptide N-tetradecanoyltransferase.
|
| Alternative Name(s) |
|---|
| Peptide N-myristoyltransferase. |
| Peptide N-tetradecanoyltransferase. |
| Reaction catalysed |
|---|
| Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] <=> CoA + an N-terminal-N-tetradecanoylglycyl-[protein] |
| Comment(s) |
|---|
- The enzyme catalyzes the transfer of myristic acid from myristoyl-CoA
to the amino group of the N-terminal glycine residue in a variety of
eukaryotic proteins.
- It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the
enzyme prior to the binding of the peptide substrate, and CoA release
precedes the release of the myristoylated peptide.
- The enzyme from yeast is profoundly affected by amino acids further
from the N-terminus, and is particularly stimulated by a serine
residue at position 5.
|
| Cross-references |
|---|
| PROSITE | PDOC00752 |
| BRENDA | 2.3.1.97 |
| EC2PDB | 2.3.1.97 |
| ExplorEnz | 2.3.1.97 |
| PRIAM enzyme-specific profiles | 2.3.1.97 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.97 |
| IUBMB Enzyme Nomenclature | 2.3.1.97 |
| IntEnz | 2.3.1.97 |
| MEDLINE | Find literature relating to 2.3.1.97 |
| MetaCyc | 2.3.1.97 |
| UniProtKB/Swiss-Prot |
| Q9LTR9, NMT1_ARATH; | P31717, NMT1_BOVIN; | P30419, NMT1_HUMAN; |
| O70310, NMT1_MOUSE; | Q5RAF3, NMT1_PONAB; | Q8K1Q0, NMT1_RAT; |
| Q94L32, NMT2_ARATH; | Q9N181, NMT2_BOVIN; | A7YT82, NMT2_DANRE; |
| O60551, NMT2_HUMAN; | O70311, NMT2_MOUSE; | P34763, NMT_AJECA; |
| Q9EMI7, NMT_AMEPV; | Q75EK2, NMT_ASHGO; | Q9UVX3, NMT_ASPFU; |
| P46548, NMT_CAEEL; | P30418, NMT_CANAL; | O74234, NMT_CANGA; |
| P0CP21, NMT_CRYNB; | P34809, NMT_CRYNE; | P0CP20, NMT_CRYNJ; |
| Q6BJF4, NMT_DEBHA; | Q553B6, NMT_DICDI; | O61613, NMT_DROME; |
| Q8TFN1, NMT_EMENI; | Q4I061, NMT_GIBZE; | Q6CMK4, NMT_KLULA; |
| Q5UR64, NMT_MIMIV; | Q9YW20, NMT_MSEPV; | Q7S3C8, NMT_NEUCR; |
| Q8ILW6, NMT_PLAF7; | O43010, NMT_SCHPO; | Q4PB56, NMT_USTMA; |
| Q6C7G2, NMT_YARLI; | P14743, NMT_YEAST; |
|
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