Due to maintenance work, this service and ftp://ftp.expasy.org will be unavailable from Tuesday August 23rd 18:00 until Wednesday August 24th 08:00
CEST. Apologies for the inconvenience.
ENZYME entry: EC 2.3.1.97
Accepted Name |
glycylpeptide N-tetradecanoyltransferase.
|
Alternative Name(s) |
peptide N-myristoyltransferase. |
peptide N-tetradecanoyltransferase. |
Reaction catalysed |
N-terminal glycyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycyl-[protein] |
Comment(s) |
- The enzyme catalyzes the transfer of myristic acid from myristoyl-CoA
to the amino group of the N-terminal glycine residue in a variety of
eukaryotic proteins.
- It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the
enzyme prior to the binding of the peptide substrate, and CoA release
precedes the release of the myristoylated peptide.
- The enzyme from yeast is profoundly affected by amino acids further
from the N-terminus, and is particularly stimulated by a serine
residue at position 5.
|
Cross-references |
BRENDA | 2.3.1.97 |
EC2PDB | 2.3.1.97 |
ExplorEnz | 2.3.1.97 |
PRIAM enzyme-specific profiles | 2.3.1.97 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.97 |
IUBMB Enzyme Nomenclature | 2.3.1.97 |
IntEnz | 2.3.1.97 |
MEDLINE | Find literature relating to 2.3.1.97 |
MetaCyc | 2.3.1.97 |
Rhea expert-curated reactions | 2.3.1.97 |
UniProtKB/Swiss-Prot |
Q9LTR9, NMT1_ARATH; | P31717, NMT1_BOVIN; | P30419, NMT1_HUMAN; |
O70310, NMT1_MOUSE; | Q5RAF3, NMT1_PONAB; | Q8K1Q0, NMT1_RAT; |
Q94L32, NMT2_ARATH; | Q9N181, NMT2_BOVIN; | A7YT82, NMT2_DANRE; |
O60551, NMT2_HUMAN; | O70311, NMT2_MOUSE; | P34763, NMT_AJECA; |
Q9EMI7, NMT_AMEPV; | Q75EK2, NMT_ASHGO; | Q9UVX3, NMT_ASPFU; |
P46548, NMT_CAEEL; | P30418, NMT_CANAL; | O74234, NMT_CANGA; |
P0CP21, NMT_CRYNB; | P34809, NMT_CRYNE; | P0CP20, NMT_CRYNJ; |
Q6BJF4, NMT_DEBHA; | Q553B6, NMT_DICDI; | O61613, NMT_DROME; |
Q8TFN1, NMT_EMENI; | Q4I061, NMT_GIBZE; | Q6CMK4, NMT_KLULA; |
Q5UR64, NMT_MIMIV; | Q9YW20, NMT_MSEPV; | Q7S3C8, NMT_NEUCR; |
Q8ILW6, NMT_PLAF7; | Q9U419, NMT_PLAFA; | O43010, NMT_SCHPO; |
Q4PB56, NMT_USTMA; | Q6C7G2, NMT_YARLI; | P14743, NMT_YEAST; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-