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ENZYME

ENZYME entry: EC 2.3.1.97

Accepted Name
glycylpeptide N-tetradecanoyltransferase
Alternative Name(s)
peptide N-myristoyltransferase
peptide N-tetradecanoyltransferase
Reaction catalysed
N-terminal glycyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycyl-[protein]
Comment(s)
  • The enzyme catalyzes the transfer of myristic acid from myristoyl-CoA to the amino group of the N-terminal glycine residue in a variety of eukaryotic proteins.
  • It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the enzyme prior to the binding of the peptide substrate, and CoA release precedes the release of the myristoylated peptide.
  • The enzyme from yeast is profoundly affected by amino acids further from the N-terminus, and is particularly stimulated by a serine residue at position 5.
Cross-references
BRENDA2.3.1.97
EC2PDB2.3.1.97
ExplorEnz2.3.1.97
PRIAM enzyme-specific profiles2.3.1.97
KEGG Ligand Database for Enzyme Nomenclature2.3.1.97
IUBMB Enzyme Nomenclature2.3.1.97
IntEnz2.3.1.97
MEDLINEFind literature relating to 2.3.1.97
MetaCyc2.3.1.97
Rhea expert-curated reactions2.3.1.97
UniProtKB/Swiss-Prot
Q9LTR9, NMT1_ARATHP31717, NMT1_BOVINP30419, NMT1_HUMAN
O70310, NMT1_MOUSEQ5RAF3, NMT1_PONABQ8K1Q0, NMT1_RAT
Q94L32, NMT2_ARATHQ9N181, NMT2_BOVINA7YT82, NMT2_DANRE
O60551, NMT2_HUMANO70311, NMT2_MOUSEP34763, NMT_AJECA
Q9EMI7, NMT_AMEPVQ75EK2, NMT_ASHGOQ9UVX3, NMT_ASPFU
P46548, NMT_CAEELP30418, NMT_CANALO74234, NMT_CANGA
P0CP21, NMT_CRYNBP34809, NMT_CRYNEP0CP20, NMT_CRYNJ
Q6BJF4, NMT_DEBHAQ553B6, NMT_DICDIO61613, NMT_DROME
Q8TFN1, NMT_EMENIQ4I061, NMT_GIBZEQ6CMK4, NMT_KLULA
Q5UR64, NMT_MIMIVQ9YW20, NMT_MSEPVQ7S3C8, NMT_NEUCR
Q8ILW6, NMT_PLAF7Q9U419, NMT_PLAFAO43010, NMT_SCHPO
Q4PB56, NMT_USTMAQ6C7G2, NMT_YARLIP14743, NMT_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-