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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.3.2.25

Accepted Name
N-terminal E2 ubiquitin-conjugating enzyme.
Alternative Name(s)
N-terminal ubiquitin-conjugating enzyme E2.
Reaction catalysed
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid <=> [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein]
Comment(s)
  • The enzyme ubiquitinylates the N-terminus of the acceptor protein.
  • It is not reactive toward free lysine.
Cross-references
BRENDA2.3.2.25
EC2PDB2.3.2.25
ExplorEnz2.3.2.25
PRIAM enzyme-specific profiles2.3.2.25
KEGG Ligand Database for Enzyme Nomenclature2.3.2.25
IUBMB Enzyme Nomenclature2.3.2.25
IntEnz2.3.2.25
MEDLINEFind literature relating to 2.3.2.25
MetaCyc2.3.2.25
UniProtKB/Swiss-Prot
Q4VBH4, UB2WA_DANRE;  Q1JPX4, UB2WB_DANRE;  A6H795, UBE2W_BOVIN;  
Q55EY8, UBE2W_DICDI;  Q96B02, UBE2W_HUMAN;  Q8VDW4, UBE2W_MOUSE;  
B5DEI4, UBE2W_RAT;  Q28FC1, UBE2W_XENTR;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-