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ENZYME entry: EC 2.3.2.29

Accepted Name
Aspartate/glutamate leucyltransferase.
Reaction catalysed
  • L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] <=> tRNA(Leu) + N-terminal L-leucyl-L-glutamyl-[protein]
  • L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] <=> tRNA(Leu) + N-terminal L-leucyl-L-aspartyl-[protein]
Comment(s)
  • The enzyme participates in the N-end rule protein degradation pathway in certain bacteria, by attaching the primary destabilizing residue L-leucine to the N-termini of proteins that have an N-terminal L-aspartate or L-glutamate residue.
  • Once modified, the proteins are recognized by EC 3.4.21.92.
  • Cf. EC 2.3.2.6 and EC 2.3.2.8.
Cross-references
BRENDA2.3.2.29
EC2PDB2.3.2.29
ExplorEnz2.3.2.29
PRIAM enzyme-specific profiles2.3.2.29
KEGG Ligand Database for Enzyme Nomenclature2.3.2.29
IUBMB Enzyme Nomenclature2.3.2.29
IntEnz2.3.2.29
MEDLINEFind literature relating to 2.3.2.29
MetaCyc2.3.2.29
UniProtKB/Swiss-Prot
A1TRT1, BPT_ACIAC;  Q6FDS2, BPT_ACIAD;  B7I7S8, BPT_ACIB5;  
B2HUQ9, BPT_ACIBC;  B0VTF8, BPT_ACIBS;  A3M311, BPT_ACIBT;  
B0V8X8, BPT_ACIBY;  B9MJA6, BPT_ACIET;  A1W7D8, BPT_ACISJ;  
A0KJD9, BPT_AERHH;  A4SNL5, BPT_AERS4;  Q8UG81, BPT_AGRFC;  
B9JCW7, BPT_AGRRK;  B9JV68, BPT_AGRVS;  Q0VQ13, BPT_ALCBS;  
Q0A7X7, BPT_ALKEH;  Q5P1A8, BPT_AROAE;  A8HXU1, BPT_AZOC5;  
Q2KW46, BPT_BORA1;  Q7WGE5, BPT_BORBR;  Q7W4W7, BPT_BORPA;  
A9I8M3, BPT_BORPD;  Q7VTR8, BPT_BORPE;  Q89K72, BPT_BRADU;  
A5EKJ1, BPT_BRASB;  A4YWA5, BPT_BRASO;  B2S504, BPT_BRUA1;  
Q2YNA4, BPT_BRUA2;  Q57DZ4, BPT_BRUAB;  A9MAD7, BPT_BRUC2;  
C0RI93, BPT_BRUMB;  P63646, BPT_BRUME;  A5VPT9, BPT_BRUO2;  
B0CL81, BPT_BRUSI;  P63647, BPT_BRUSU;  B1YPI7, BPT_BURA4;  
Q1BWM3, BPT_BURCA;  B1K0S5, BPT_BURCC;  A0K730, BPT_BURCH;  
B4E8N5, BPT_BURCJ;  Q0BFQ9, BPT_BURCM;  Q39GX4, BPT_BURL3;  
A9AJX3, BPT_BURM1;  A3MJ99, BPT_BURM7;  A2S373, BPT_BURM9;  
Q62K46, BPT_BURMA;  A1V4A4, BPT_BURMS;  A3NUS2, BPT_BURP0;  
Q3JSS7, BPT_BURP1;  A3N926, BPT_BURP6;  Q63TV2, BPT_BURPS;  
Q2SVM0, BPT_BURTA;  A4JE23, BPT_BURVG;  A8FM84, BPT_CAMJ8;  
A7H303, BPT_CAMJD;  Q9PNQ6, BPT_CAMJE;  A1W023, BPT_CAMJJ;  
Q5HU66, BPT_CAMJR;  Q9A7Z5, BPT_CAUVC;  B8GVD8, BPT_CAUVN;  
B3PL52, BPT_CELJU;  Q11JA2, BPT_CHESB;  Q1QUS3, BPT_CHRSD;  
Q7NX30, BPT_CHRVO;  Q480P3, BPT_COLP3;  Q1LP26, BPT_CUPMC;  
Q0KBT3, BPT_CUPNH;  Q472J5, BPT_CUPPJ;  B3R4T1, BPT_CUPTR;  
Q47GT0, BPT_DECAR;  A9BME3, BPT_DELAS;  A8LSL0, BPT_DINSH;  
A9HRQ0, BPT_GLUDA;  Q5FUV3, BPT_GLUOX;  Q0BTF8, BPT_GRABC;  
Q2SJK9, BPT_HAHCH;  A1WWV3, BPT_HALHL;  P59794, BPT_HELHP;  
A4G7T6, BPT_HERAR;  Q0C3S3, BPT_HYPNA;  A6T105, BPT_JANMA;  
Q28R42, BPT_JANSC;  Q04SK8, BPT_LEPBJ;  Q050N5, BPT_LEPBL;  
B1Y1E7, BPT_LEPCP;  Q72R21, BPT_LEPIC;  Q8F4R6, BPT_LEPIN;  
Q2W440, BPT_MAGSA;  A1U1G9, BPT_MARHV;  Q0APD6, BPT_MARMM;  
B7KPZ2, BPT_METC4;  A9VY56, BPT_METEP;  Q1H2E4, BPT_METFK;  
B8IPM0, BPT_METNO;  B1ZJU3, BPT_METPB;  A2SFU1, BPT_METPP;  
B0UJ71, BPT_METS4;  Q82ST4, BPT_NITEU;  Q1QL63, BPT_NITHX;  
Q2Y5H6, BPT_NITMU;  Q3J7Z6, BPT_NITOC;  Q3SRC0, BPT_NITWN;  
Q2G9C7, BPT_NOVAD;  A6X1Z7, BPT_OCHA4;  B6JGH2, BPT_OLICO;  
A1B416, BPT_PARDP;  A7HX57, BPT_PARL1;  B2JKL8, BPT_PARP8;  
B2T3H8, BPT_PARPJ;  Q13ZM2, BPT_PARXL;  B4RBQ2, BPT_PHEZH;  
A4SWU6, BPT_POLAQ;  A1VN09, BPT_POLNA;  B1XV76, BPT_POLNS;  
Q12B44, BPT_POLSJ;  Q48H68, BPT_PSE14;  Q15TA0, BPT_PSEA6;  
A6V4G8, BPT_PSEA7;  B7UV23, BPT_PSEA8;  Q02NB0, BPT_PSEAB;  
Q9I0M0, BPT_PSEAE;  Q1IBD6, BPT_PSEE4;  Q4K9V0, BPT_PSEF5;  
C3JY60, BPT_PSEFS;  A4XUY1, BPT_PSEMY;  A5W1H0, BPT_PSEP1;  
Q3KA78, BPT_PSEPF;  B0KLX4, BPT_PSEPG;  Q88FS6, BPT_PSEPK;  
B1JBE6, BPT_PSEPW;  Q87ZS3, BPT_PSESM;  Q4ZRK9, BPT_PSEU2;  
A4VLV4, BPT_PSEU5;  B2UFW5, BPT_RALPJ;  Q8XYZ0, BPT_RALSO;  
Q2KA31, BPT_RHIEC;  Q1MIV1, BPT_RHIL3;  Q983E4, BPT_RHILO;  
B5ZX28, BPT_RHILW;  Q92KF8, BPT_RHIME;  Q21VY8, BPT_RHOFT;  
Q2IWT7, BPT_RHOP2;  Q07M86, BPT_RHOP5;  Q6N6A7, BPT_RHOPA;  
Q214I7, BPT_RHOPB;  Q136V2, BPT_RHOPS;  B3QJI8, BPT_RHOPT;  
Q2RTA0, BPT_RHORT;  A3PJ90, BPT_RHOS1;  Q3J340, BPT_RHOS4;  
B9KRL8, BPT_RHOSK;  Q165K9, BPT_ROSDO;  Q5LQC3, BPT_RUEPO;  
Q1GIA1, BPT_RUEST;  Q21K29, BPT_SACD2;  A1S7A3, BPT_SHEAM;  
Q8EDW7, BPT_SHEON;  A4Y7L3, BPT_SHEPC;  A0KW19, BPT_SHESA;  
Q0HJP1, BPT_SHESM;  Q0HVY7, BPT_SHESR;  A6U7N6, BPT_SINMW;  
Q1GWA7, BPT_SPHAL;  P59795, BPT_SPHEL;  A5V8Y6, BPT_SPHWW;  
B4SP02, BPT_STRM5;  B2FTC1, BPT_STRMK;  C5BIJ7, BPT_TERTT;  
Q3SH94, BPT_THIDA;  C5CYP5, BPT_VARPS;  A1WNY2, BPT_VEREI;  
A5F7F2, BPT_VIBC3;  A7N1L8, BPT_VIBCB;  Q9KRA6, BPT_VIBCH;  
C3LN58, BPT_VIBCM;  Q87QY2, BPT_VIBPA;  Q8DAR7, BPT_VIBVU;  
Q7MJ43, BPT_VIBVY;  Q8PN34, BPT_XANAC;  Q3BW59, BPT_XANC5;  
Q4US26, BPT_XANC8;  B0RY43, BPT_XANCB;  Q8PBH8, BPT_XANCP;  
Q2P5C8, BPT_XANOM;  B2STA8, BPT_XANOP;  Q5H2F6, BPT_XANOR;  
A7INB9, BPT_XANP2;  B2I7M5, BPT_XYLF2;  Q9PEL0, BPT_XYLFA;  
B0U219, BPT_XYLFM;  Q87EJ8, BPT_XYLFT;  

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