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ENZYME entry: EC 2.3.2.29

Accepted Name
aspartate/glutamate leucyltransferase
Reaction catalysed
  • L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] <=> H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)
  • L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] <=> H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)
Comment(s)
  • The enzyme participates in the N-end rule protein degradation pathway in certain bacteria, by attaching the primary destabilizing residue L-leucine to the N-termini of proteins that have an N-terminal L-aspartate or L-glutamate residue.
  • Once modified, the proteins are recognized by EC 3.4.21.92. cf. EC 2.3.2.6 and EC 2.3.2.8.
Cross-references
BRENDA2.3.2.29
EC2PDB2.3.2.29
ExplorEnz2.3.2.29
PRIAM enzyme-specific profiles2.3.2.29
KEGG Ligand Database for Enzyme Nomenclature2.3.2.29
IUBMB Enzyme Nomenclature2.3.2.29
IntEnz2.3.2.29
MEDLINEFind literature relating to 2.3.2.29
MetaCyc2.3.2.29
Rhea expert-curated reactions2.3.2.29
UniProtKB/Swiss-Prot
Q6FDS2, BPT_ACIADB7I7S8, BPT_ACIB5B2HUQ9, BPT_ACIBC
B0VTF8, BPT_ACIBSA3M311, BPT_ACIBTB0V8X8, BPT_ACIBY
B9MJA6, BPT_ACIETA1W7D8, BPT_ACISJA0KJD9, BPT_AERHH
A4SNL5, BPT_AERS4B6JGH2, BPT_AFIC5Q8UG81, BPT_AGRFC
Q21VY8, BPT_ALBFTQ0VQ13, BPT_ALCBSQ0A7X7, BPT_ALKEH
B9JV68, BPT_ALLAMQ5P1A8, BPT_AROAEA8HXU1, BPT_AZOC5
Q2KW46, BPT_BORA1Q7WGE5, BPT_BORBRQ7W4W7, BPT_BORPA
A9I8M3, BPT_BORPDQ7VTR8, BPT_BORPEQ89K72, BPT_BRADU
A5EKJ1, BPT_BRASBA4YWA5, BPT_BRASOB2S504, BPT_BRUA1
Q2YNA4, BPT_BRUA2A6X1Z7, BPT_BRUA4Q57DZ4, BPT_BRUAB
A9MAD7, BPT_BRUC2C0RI93, BPT_BRUMBP63646, BPT_BRUME
A5VPT9, BPT_BRUO2B0CL81, BPT_BRUSIP63647, BPT_BRUSU
B1YPI7, BPT_BURA4A0K730, BPT_BURCHB4E8N5, BPT_BURCJ
Q0BFQ9, BPT_BURCMQ39GX4, BPT_BURL3A9AJX3, BPT_BURM1
A3MJ99, BPT_BURM7A2S373, BPT_BURM9Q62K46, BPT_BURMA
A1V4A4, BPT_BURMSB1K0S5, BPT_BURO0Q1BWM3, BPT_BURO1
A3NUS2, BPT_BURP0Q3JSS7, BPT_BURP1A3N926, BPT_BURP6
Q63TV2, BPT_BURPSQ2SVM0, BPT_BURTAA4JE23, BPT_BURVG
A8FM84, BPT_CAMJ8A7H303, BPT_CAMJDQ9PNQ6, BPT_CAMJE
A1W023, BPT_CAMJJQ5HU66, BPT_CAMJRQ9A7Z5, BPT_CAUVC
B8GVD8, BPT_CAUVNB3PL52, BPT_CELJUA3PJ90, BPT_CERS1
Q3J340, BPT_CERS4B9KRL8, BPT_CERSKQ11JA2, BPT_CHESB
Q1QUS3, BPT_CHRSDQ7NX30, BPT_CHRVOQ480P3, BPT_COLP3
Q1LP26, BPT_CUPMCQ0KBT3, BPT_CUPNHQ472J5, BPT_CUPPJ
B3R4T1, BPT_CUPTRQ47GT0, BPT_DECARA9BME3, BPT_DELAS
A8LSL0, BPT_DINSHA9HRQ0, BPT_GLUDAQ5FUV3, BPT_GLUOX
Q0BTF8, BPT_GRABCQ2SJK9, BPT_HAHCHA1WWV3, BPT_HALHL
P59794, BPT_HELHPA4G7T6, BPT_HERARQ0C3S3, BPT_HYPNA
A6T105, BPT_JANMAQ28R42, BPT_JANSCQ04SK8, BPT_LEPBJ
Q050N5, BPT_LEPBLB1Y1E7, BPT_LEPCPQ72R21, BPT_LEPIC
Q8F4R6, BPT_LEPINQ2W440, BPT_MAGSAQ0APD6, BPT_MARMM
A1U1G9, BPT_MARN8B7KPZ2, BPT_METC4A9VY56, BPT_METEP
Q1H2E4, BPT_METFKB8IPM0, BPT_METNOB1ZJU3, BPT_METPB
A2SFU1, BPT_METPPB0UJ71, BPT_METS4Q82ST4, BPT_NITEU
Q1QL63, BPT_NITHXQ2Y5H6, BPT_NITMUQ3J7Z6, BPT_NITOC
Q3SRC0, BPT_NITWNQ2G9C7, BPT_NOVADA1TRT1, BPT_PARC0
A1B416, BPT_PARDPA7HX57, BPT_PARL1B2JKL8, BPT_PARP8
B2T3H8, BPT_PARPJQ13ZM2, BPT_PARXLB4RBQ2, BPT_PHEZH
A4SWU6, BPT_POLAQA1VN09, BPT_POLNAB1XV76, BPT_POLNS
Q12B44, BPT_POLSJQ48H68, BPT_PSE14Q15TA0, BPT_PSEA6
A6V4G8, BPT_PSEA7B7UV23, BPT_PSEA8Q02NB0, BPT_PSEAB
Q9I0M0, BPT_PSEAEQ1IBD6, BPT_PSEE4Q4K9V0, BPT_PSEF5
C3JY60, BPT_PSEFSA4XUY1, BPT_PSEMYA5W1H0, BPT_PSEP1
Q3KA78, BPT_PSEPFB0KLX4, BPT_PSEPGQ88FS6, BPT_PSEPK
B1JBE6, BPT_PSEPWQ87ZS3, BPT_PSESMQ4ZRK9, BPT_PSEU2
Q8XYZ0, BPT_RALN1B2UFW5, BPT_RALPJQ2KA31, BPT_RHIEC
Q1MIV1, BPT_RHIJ3Q983E4, BPT_RHILOB5ZX28, BPT_RHILW
Q92KF8, BPT_RHIMEB9JCW7, BPT_RHIR8A5V8Y6, BPT_RHIWR
Q2IWT7, BPT_RHOP2Q07M86, BPT_RHOP5Q6N6A7, BPT_RHOPA
Q214I7, BPT_RHOPBQ136V2, BPT_RHOPSB3QJI8, BPT_RHOPT
Q2RTA0, BPT_RHORTQ165K9, BPT_ROSDOQ5LQC3, BPT_RUEPO
Q1GIA1, BPT_RUESTQ21K29, BPT_SACD2A1S7A3, BPT_SHEAM
Q8EDW7, BPT_SHEONA4Y7L3, BPT_SHEPCA0KW19, BPT_SHESA
Q0HJP1, BPT_SHESMQ0HVY7, BPT_SHESRA6U7N6, BPT_SINMW
Q1GWA7, BPT_SPHALP59795, BPT_SPHELB4SP02, BPT_STRM5
B2FTC1, BPT_STRMKA4VLV4, BPT_STUS1C5BIJ7, BPT_TERTT
Q3SH94, BPT_THIDAC5CYP5, BPT_VARPSA1WNY2, BPT_VEREI
A7N1L8, BPT_VIBC1A5F7F2, BPT_VIBC3Q9KRA6, BPT_VIBCH
C3LN58, BPT_VIBCMQ87QY2, BPT_VIBPAQ8DAR7, BPT_VIBVU
Q7MJ43, BPT_VIBVYQ8PN34, BPT_XANACQ3BW59, BPT_XANC5
Q4US26, BPT_XANC8B0RY43, BPT_XANCBQ8PBH8, BPT_XANCP
Q2P5C8, BPT_XANOMB2STA8, BPT_XANOPQ5H2F6, BPT_XANOR
A7INB9, BPT_XANP2B2I7M5, BPT_XYLF2Q9PEL0, BPT_XYLFA
B0U219, BPT_XYLFMQ87EJ8, BPT_XYLFT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
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