ID   2.3.2.32
DE   cullin-RING-type E3 NEDD8 transferase.
CA   S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-
CA   L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-
CA   protein]-yl-[cullin]-L-lysine.
CC   -!- Some RING-type E3 ubiquitin transferase (EC 2.3.2.27) are not able to
CC       bind a substrate protein directly.
CC   -!- Instead, they form a complex with a cullin scaffold protein and a
CC       substrate recognition module, which is named CRL for Cullin-RING-
CC       Ligase.
CC   -!- The cullin protein needs to be activated by the ubiquitin-like
CC       protein NEDD8 in a process known as neddylation.
CC   -!- The transfer of NEDD8 from a NEDD8-specific E2 enzyme onto the cullin
CC       protein is a secondary function of the RING-type E3 ubiquitin
CC       transferase in the CRL complex.
CC   -!- The process requires auxiliary factors that belong to the DCN1
CC       (defective in cullin neddylation 1) family.
DR   P62877, RBX1_HUMAN ;  P62878, RBX1_MOUSE ;  Q1RMW1, UBE2F_BOVIN;
DR   Q5ZKX6, UBE2F_CHICK;  Q6NY82, UBE2F_DANRE;  Q969M7, UBE2F_HUMAN;
DR   Q5U203, UBE2F_RAT  ;  Q6IRC7, UBE2F_XENLA;  Q5M8Y2, UBE2F_XENTR;
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