ID   2.3.2.34
DE   E2 NEDD8-conjugating enzyme.
AN   NEDD8-carrier-protein E2.
AN   NEDD8-conjugating enzyme E2.
CA   [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-
CA   conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine
CA   + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.
CC   -!- Some RING-type E3 ubiquitin transferases (EC 2.3.2.27) are not able
CC       to bind a substrate protein directly.
CC   -!- Instead, they form complexes with a cullin scaffold protein and a
CC       substrate recognition module, which are known as CRL (Cullin-RING-
CC       Ligase) complexes.
CC   -!- The cullin protein needs to be activated by the ubiquitin-like
CC       protein NEDD8 in a process known as neddylation.
CC   -!- Like ubiquitin, the NEDD8 protein ends with two glycine residues.
CC   -!- EC 6.2.1.64 activates NEDD8 in an ATP-dependent reaction by forming a
CC       high-energy thioester intermediate between NEDD8 and one of its
CC       cysteine residues.
CC   -!- The activated NEDD8 is subsequently transferred to a cysteine residue
CC       of an E2 NEDD8-conjugating enzyme, and is eventually conjugated to a
CC       lysine residue of specific substrates in the presence of the
CC       appropriate E3 transferase (EC 2.3.2.32).
DR   Q9CY34, UB2FA_MOUSE;  Q3UWQ3, UB2FB_MOUSE;  A3KN22, UBC12_BOVIN;
DR   Q9XVK5, UBC12_CAEEL;  Q6FVQ8, UBC12_CANGA;  Q54TI6, UBC12_DICDI;
DR   Q75AF2, UBC12_EREGS;  P61081, UBC12_HUMAN;  Q6CSW8, UBC12_KLULA;
DR   P61082, UBC12_MOUSE;  O74549, UBC12_SCHPO;  Q6DCZ9, UBC12_XENLA;
DR   Q6P8D9, UBC12_XENTR;  Q6C9W0, UBC12_YARLI;  P52491, UBC12_YEAST;
DR   Q9VSF3, UBC2M_DROME;
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