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ENZYME entry: EC 2.3.2.36

Accepted Name
RING-type E3 ubiquitin transferase (cysteine targeting).
Alternative Name(s)
RING E3 ligase.
Reaction catalysed
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine <=> [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine
Comment(s)
  • This relatively rare subpopulation of RING-type E3 ubiquitin transferases (cf. EC 2.3.2.27), found in mammals and herpes viruses, can transfer ubiquitin to a cysteine residue in target proteins.
  • Additional ubiquitin molecules are polymerized on top of the initial ubiquitin molecule by formation of an isopeptide linkage with lysine(48) in the pre-attached ubiquitin (2).
Cross-references
BRENDA2.3.2.36
EC2PDB2.3.2.36
ExplorEnz2.3.2.36
PRIAM enzyme-specific profiles2.3.2.36
KEGG Ligand Database for Enzyme Nomenclature2.3.2.36
IUBMB Enzyme Nomenclature2.3.2.36
IntEnz2.3.2.36
MEDLINEFind literature relating to 2.3.2.36
MetaCyc2.3.2.36
Rhea expert-curated reactions2.3.2.36
UniProtKB/Swiss-Prot
Q9UKV5, AMFR_HUMAN;  Q9R049, AMFR_MOUSE;  P90495, MIR1_HHV8P;  
O41933, MIR1_MHV68;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-