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ENZYME

ENZYME entry: EC 2.3.2.36

PURL: https://purl.expasy.org/enzyme/EC/2.3.2.36
Accepted Name
RING-type E3 ubiquitin transferase (cysteine targeting)
Alternative Name(s)
RING E3 ligase
Reaction catalysed
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine
Comment(s)
  • This relatively rare subpopulation of RING-type E3 ubiquitin transferases (cf. EC 2.3.2.27), found in mammals and herpes viruses, can transfer ubiquitin to a cysteine residue in target proteins.
  • Additional ubiquitin molecules are polymerized on top of the initial ubiquitin molecule by formation of an isopeptide linkage with lysine(48) in the pre-attached ubiquitin.
Cross-references
BRENDA2.3.2.36
EC2PDB2.3.2.36
ExplorEnz2.3.2.36
KEGG Ligand Database for Enzyme Nomenclature2.3.2.36
IUBMB Enzyme Nomenclature2.3.2.36
MEDLINEFind literature relating to 2.3.2.36
MetaCyc2.3.2.36
Rhea expert-curated reactions2.3.2.36
UniProtKB/Swiss-Prot
F1QB30, AMFR_DANREQ9UKV5, AMFR_HUMANQ9R049, AMFR_MOUSE
P90495, MIR1_HHV8PO41933, MIR1_MHV68Q96PU5, NED4L_HUMAN
Q8CFI0, NED4L_MOUSEQ9CA86, PEX2_ARATHQ06438, PEX2_CRIGR
E7F4V8, PEX2_DANREQ75JQ3, PEX2_DICDIP28328, PEX2_HUMAN
C4R3D4, PEX2_KOMPGP55098, PEX2_MOUSEQ01964, PEX2_PICPA
P51021, PEX2_PODASP24392, PEX2_RATG2Q1C9, PEX2_THET4
A0A1L8FZ98, PEX2_XENLAQ99155, PEX2_YARLIP32800, PEX2_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
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