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ENZYME

ENZYME entry: EC 2.3.2.5

Accepted Name
glutaminyl-peptide cyclotransferase
Alternative Name(s)
glutaminyl cyclase
glutaminyl-tRNA cyclotransferase
Reaction catalysed
N-terminal L-glutaminyl-[peptide] <=> N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)
Comment(s)
  • Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues.
  • The enzyme from papaya also acts on glutaminyl-tRNA.
Cross-references
BRENDA2.3.2.5
EC2PDB2.3.2.5
ExplorEnz2.3.2.5
PRIAM enzyme-specific profiles2.3.2.5
KEGG Ligand Database for Enzyme Nomenclature2.3.2.5
IUBMB Enzyme Nomenclature2.3.2.5
IntEnz2.3.2.5
MEDLINEFind literature relating to 2.3.2.5
MetaCyc2.3.2.5
Rhea expert-curated reactions2.3.2.5
UniProtKB/Swiss-Prot
Q9VRQ9, QPCT1_DROMEQ86PD7, QPCT2_DROMEQ0V8G3, QPCTL_BOVIN
Q9NXS2, QPCTL_HUMANQ4R942, QPCTL_MACFAQ8BH73, QPCTL_MOUSE
Q84WV9, QPCT_ARATHA7ISW2, QPCT_BOIDEA7ISW1, QPCT_BOIIR
Q9YIB5, QPCT_BOTJAQ28120, QPCT_BOVINP0CV92, QPCT_CROAT
Q54B14, QPCT_DICDIQ90YA8, QPCT_GLOBLQ16769, QPCT_HUMAN
B7QK46, QPCT_IXOSCQ9CYK2, QPCT_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-