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ENZYME entry: EC 2.3.2.5

Accepted Name
glutaminyl-peptide cyclotransferase.
Alternative Name(s)
glutaminyl cyclase.
glutaminyl-tRNA cyclotransferase.
Reaction catalysed
N-terminal L-glutaminyl-[peptide] <=> N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)
Comment(s)
  • Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues.
  • The enzyme from papaya also acts on glutaminyl-tRNA.
Cross-references
BRENDA2.3.2.5
EC2PDB2.3.2.5
ExplorEnz2.3.2.5
PRIAM enzyme-specific profiles2.3.2.5
KEGG Ligand Database for Enzyme Nomenclature2.3.2.5
IUBMB Enzyme Nomenclature2.3.2.5
IntEnz2.3.2.5
MEDLINEFind literature relating to 2.3.2.5
MetaCyc2.3.2.5
Rhea expert-curated reactions2.3.2.5
UniProtKB/Swiss-Prot
Q0V8G3, QPCTL_BOVIN;  Q9NXS2, QPCTL_HUMAN;  Q4R942, QPCTL_MACFA;  
Q8BH73, QPCTL_MOUSE;  Q84WV9, QPCT_ARATH;  A7ISW2, QPCT_BOIDE;  
A7ISW1, QPCT_BOIIR;  Q9YIB5, QPCT_BOTJA;  Q28120, QPCT_BOVIN;  
P0CV92, QPCT_CROAT;  Q54B14, QPCT_DICDI;  Q90YA8, QPCT_GLOBL;  
Q16769, QPCT_HUMAN;  B7QK46, QPCT_IXOSC;  Q9CYK2, QPCT_MOUSE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
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