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ENZYME entry: EC 2.3.3.1

Accepted Name
citrate (Si)-synthase.
Alternative Name(s)
(R)-citrate synthase.
citrate oxaloacetate-lyase [(pro-3S)-CH2COO->acetyl-CoA].
Reaction catalysed
acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H(+)
Comment(s)
  • The stereospecificity of this enzyme is opposite to that of EC 2.3.3.3, which is found in some anaerobes.
  • Citrate synthase for which the stereospecificity with respect to C2 of oxaloacetate has not been established are included in EC 2.3.3.16.
  • Formerly EC 4.1.3.7.
Cross-references
BRENDA2.3.3.1
EC2PDB2.3.3.1
ExplorEnz2.3.3.1
PRIAM enzyme-specific profiles2.3.3.1
KEGG Ligand Database for Enzyme Nomenclature2.3.3.1
IUBMB Enzyme Nomenclature2.3.3.1
IntEnz2.3.3.1
MEDLINEFind literature relating to 2.3.3.1
MetaCyc2.3.3.1
Rhea expert-curated reactions2.3.3.1
UniProtKB/Swiss-Prot
P00890, CISY1_YEAST;  P43635, CISY3_YEAST;  Q0GNE1, CISY_AMBCR;  
Q29RK1, CISY_BOVIN;  P23007, CISY_CHICK;  Q7ZVY5, CISY_DANRE;  
O75390, CISY_HUMAN;  Q0GNE0, CISY_IGUIG;  Q6S9V5, CISY_KAJAU;  
Q6S9V7, CISY_KATPE;  P0C1Z2, CISY_MACFA;  Q0QEL7, CISY_MESAU;  
Q9CZU6, CISY_MOUSE;  P00889, CISY_PIG;  Q8VHF5, CISY_RAT;  
Q4S5X1, CISY_TETNG;  Q6S9V9, CISY_THUAL;  Q6S9V8, CISY_THUOB;  
Q7ZWZ5, CISY_XENLA;  Q28DK1, CISY_XENTR;  Q6S9V6, CISY_XIPGL;  

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