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ENZYME

ENZYME entry: EC 2.3.3.10

PURL: https://purl.expasy.org/enzyme/EC/2.3.3.10
Accepted Name
hydroxymethylglutaryl-CoA synthase
Alternative Name(s)
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating)
3-hydroxy-3-methylglutaryl-CoA synthase
3-hydroxy-3-methylglutaryl CoA synthetase
3-hydroxy-3-methylglutaryl coenzyme A synthase
3-hydroxy-3-methylglutaryl-coenzyme A synthase
3-hydroxy-3-methylglutaryl coenzyme A synthetase
acetoacetyl coenzyme A transacetase
beta-hydroxy-beta-methylglutaryl-CoA synthase
HMG-CoA synthase
hydroxymethylglutaryl coenzyme alpha-condensing enzyme
hydroxymethylglutaryl coenzyme A synthase
Reaction catalysed
acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)
Comment(s)
Formerly EC 4.1.3.5.
Cross-references
BRENDA2.3.3.10
EC2PDB2.3.3.10
ExplorEnz2.3.3.10
KEGG Ligand Database for Enzyme Nomenclature2.3.3.10
IUBMB Enzyme Nomenclature2.3.3.10
MEDLINEFind literature relating to 2.3.3.10
MetaCyc2.3.3.10
Rhea expert-curated reactions2.3.3.10
UniProtKB/Swiss-Prot
Q4WBQ3, ER13A_ASPFUQ4WXT8, ER13B_ASPFUA0A1D8PTW6, ERG13_CANAL
K7PL94, ERG13_GANLUI1RY35, ERG13_GIBZEP54874, ERG13_SCHPO
P54839, ERG13_YEASTA0A6S5ZZ88, G431_FUSSXQ4P3F1, HCS1_MYCMD
F9X3D9, HCS1_ZYMTIP54961, HMCS1_BLAGEP23228, HMCS1_CHICK
P13704, HMCS1_CRIGRQ01581, HMCS1_HUMANQ8JZK9, HMCS1_MOUSE
Q5R7Z9, HMCS1_PONABP17425, HMCS1_RATP54870, HMCS2_BLAGE
Q2KIE6, HMCS2_BOVINP54868, HMCS2_HUMANP54869, HMCS2_MOUSE
O02734, HMCS2_PIGP22791, HMCS2_RATP54872, HMCSA_DICDI
Q86HL5, HMCSB_DICDIP54873, HMCS_ARATHP54871, HMCS_CAEEL
Q9YAS0, HMGCS_AERPEO30256, HMGCS_ARCFUA8ME61, HMGCS_CALMQ
Q9FD71, HMGCS_ENTFLD4GWR6, HMGCS_HALVDQ8TIV0, HMGCS_METAC
Q0W7K1, HMGCS_METARQ46F10, HMGCS_METBFQ12UR3, HMGCS_METBU
Q58941, HMGCS_METJAQ8TVL0, HMGCS_METKAA4FWW6, HMGCS_METM5
A9AAA1, HMGCS_METM6A6VGF1, HMGCS_METM7Q8PYJ0, HMGCS_METMA
Q6LXY3, HMGCS_METMPA5UNI8, HMGCS_METS3A4YH99, HMGCS_METS5
Q2NHU7, HMGCS_METSTO26883, HMGCS_METTHA0A384E143, HMGCS_METTL
A0B8Z1, HMGCS_METTPA6UPL1, HMGCS_METVSQ6L233, HMGCS_PICTO
Q9UYY8, HMGCS_PYRABQ8ZVP4, HMGCS_PYRAEA4WJ12, HMGCS_PYRAR
A3MV40, HMGCS_PYRCJQ51798, HMGCS_PYRFUO58410, HMGCS_PYRHO
A1RSQ5, HMGCS_PYRILB1Y953, HMGCS_PYRNVC3NGT0, HMGCS_SACI1
C3MQN6, HMGCS_SACI2C3N6F6, HMGCS_SACI3C3MWN6, HMGCS_SACI4
C4KHX1, HMGCS_SACI6C3NEW4, HMGCS_SACI7Q9UWU0, HMGCS_SACS2
Q4J933, HMGCS_SULACQ971K8, HMGCS_SULTOQ9HI87, HMGCS_THEAC
C5A401, HMGCS_THEGJQ5JFL6, HMGCS_THEKOB6YXH7, HMGCS_THEON
C6A2L5, HMGCS_THESMQ97CG9, HMGCS_THEVO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.3.-
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