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ENZYME entry: EC 2.3.3.10

Accepted Name
hydroxymethylglutaryl-CoA synthase.
Alternative Name(s)
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating).
3-hydroxy-3-methylglutaryl-CoA synthase.
3-hydroxy-3-methylglutaryl CoA synthetase.
3-hydroxy-3-methylglutaryl coenzyme A synthase.
3-hydroxy-3-methylglutaryl-coenzyme A synthase.
3-hydroxy-3-methylglutaryl coenzyme A synthetase.
acetoacetyl coenzyme A transacetase.
beta-hydroxy-beta-methylglutaryl-CoA synthase.
HMG-CoA synthase.
hydroxymethylglutaryl coenzyme alpha-condensing enzyme.
hydroxymethylglutaryl coenzyme A synthase.
Reaction catalysed
acetoacetyl-CoA + acetyl-CoA + H2O <=> (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)
Comment(s)
Formerly EC 4.1.3.5.
Cross-references
BRENDA2.3.3.10
EC2PDB2.3.3.10
ExplorEnz2.3.3.10
PRIAM enzyme-specific profiles2.3.3.10
KEGG Ligand Database for Enzyme Nomenclature2.3.3.10
IUBMB Enzyme Nomenclature2.3.3.10
IntEnz2.3.3.10
MEDLINEFind literature relating to 2.3.3.10
MetaCyc2.3.3.10
Rhea expert-curated reactions2.3.3.10
UniProtKB/Swiss-Prot
Q4WBQ3, ER13A_ASPFU;  Q4WXT8, ER13B_ASPFU;  A0A1D8PTW6, ERG13_CANAL;  
K7PL94, ERG13_GANLU;  I1RY35, ERG13_GIBZE;  P54874, ERG13_SCHPO;  
P54839, ERG13_YEAST;  A0A6S5ZZ88, G431_FUSSX;  Q4P3F1, HCS1_USTMA;  
F9X3D9, HCS1_ZYMTI;  P54961, HMCS1_BLAGE;  P23228, HMCS1_CHICK;  
P13704, HMCS1_CRIGR;  Q01581, HMCS1_HUMAN;  Q8JZK9, HMCS1_MOUSE;  
Q5R7Z9, HMCS1_PONAB;  P17425, HMCS1_RAT;  P54870, HMCS2_BLAGE;  
Q2KIE6, HMCS2_BOVIN;  P54868, HMCS2_HUMAN;  P54869, HMCS2_MOUSE;  
O02734, HMCS2_PIG;  P22791, HMCS2_RAT;  P54872, HMCSA_DICDI;  
Q86HL5, HMCSB_DICDI;  P54873, HMCS_ARATH;  P54871, HMCS_CAEEL;  
Q9FD71, HMGCS_ENTFL;  D4GWR6, HMGCS_HALVD;  

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