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ENZYME

ENZYME entry: EC 2.3.3.13

Accepted Name
2-isopropylmalate synthase
Alternative Name(s)
3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)
alpha-IPM synthetase
alpha-isopropylmalate synthase
alpha-isopropylmalate synthetase
alpha-isopropylmalic synthetase
isopropylmalate synthase
isopropylmalate synthetase
Reaction catalysed
3-methyl-2-oxobutanoate + acetyl-CoA + H2O <=> (2S)-2-isopropylmalate + CoA + H(+)
Comment(s)
Formerly EC 4.1.3.12.
Cross-references
BRENDA2.3.3.13
EC2PDB2.3.3.13
ExplorEnz2.3.3.13
PRIAM enzyme-specific profiles2.3.3.13
KEGG Ligand Database for Enzyme Nomenclature2.3.3.13
IUBMB Enzyme Nomenclature2.3.3.13
IntEnz2.3.3.13
MEDLINEFind literature relating to 2.3.3.13
MetaCyc2.3.3.13
Rhea expert-curated reactions2.3.3.13
UniProtKB/Swiss-Prot
C9K7B8, AMT7_ALTALS3D9F8, GLOH_GLAL2K0E4E5, HTYA_ASPRU
Q9LPR4, LEU11_ARATHQ8RDK3, LEU11_CALS4Q8F445, LEU11_LEPIN
Q9C550, LEU12_ARATHA8FAK7, LEU12_BACP2Q8RCF9, LEU12_CALS4
Q31EF5, LEU12_HYDCUQ8F8T4, LEU12_LEPINQ8XSZ5, LEU12_RALSO
O04973, LEU1A_SOLPNO04974, LEU1B_SOLPNE3PVH7, LEU1_ACESD
A3DF94, LEU1_ACET2A1TRT4, LEU1_ACIACB9MA32, LEU1_ACIET
C7M0E4, LEU1_ACIFDA1W6T7, LEU1_ACISJA0KGM9, LEU1_AERHH
A4SR62, LEU1_AERS4B6JB87, LEU1_AFIC5Q8UD63, LEU1_AGRFC
Q21VZ1, LEU1_ALBFTQ0VLR3, LEU1_ALCBSA8ES07, LEU1_ALIB4
Q5E856, LEU1_ALIF1B5FGH4, LEU1_ALIFMB6ELK0, LEU1_ALISL
Q5WEN3, LEU1_ALKCKB7GH19, LEU1_ANOFWO67862, LEU1_AQUAE
O30020, LEU1_ARCFUQ5NXN2, LEU1_AROAEA0JX36, LEU1_ARTS2
A1KBD3, LEU1_AZOSBC1DE40, LEU1_AZOVDC3P4Z6, LEU1_BACAA
C3L9Q7, LEU1_BACACA0RBL2, LEU1_BACAHQ81T68, LEU1_BACAN
B7JFY5, LEU1_BACC0Q73BA0, LEU1_BACC1C1EMA9, LEU1_BACC3
A7GMU1, LEU1_BACCNB9IUZ0, LEU1_BACCQQ63DX8, LEU1_BACCZ
Q6HLF3, LEU1_BACHKQ65GI8, LEU1_BACLDA9VLG7, LEU1_BACMK
A8FFW5, LEU1_BACP2P94565, LEU1_BACSUA7Z7B8, LEU1_BACVZ
B7GT76, LEU1_BIFLSQ7VQJ6, LEU1_BLOFLQ493R0, LEU1_BLOPB
A9HW07, LEU1_BORPDQ89GB0, LEU1_BRADUA5EP79, LEU1_BRASB
A4YZ76, LEU1_BRASOC0Z9C8, LEU1_BREBNQ8YIJ3, LEU1_BRUME
Q8FZC4, LEU1_BRUSUQ9ZEY8, LEU1_BUCAIO85063, LEU1_BUCAP
Q89A49, LEU1_BUCBPQ5WQ01, LEU1_BUCCCO85070, LEU1_BUCDN
Q9EVG4, LEU1_BUCMLP58898, LEU1_BUCPSP48571, LEU1_BUCRP
O31287, LEU1_BUCTSQ9EVH6, LEU1_BUCUEQ9EVE3, LEU1_BUCUL
Q9EVH0, LEU1_BUCUMQ9EVI8, LEU1_BUCUNB1YTR7, LEU1_BURA4
A0K933, LEU1_BURCHB4E5N2, LEU1_BURCJQ0BDB9, LEU1_BURCM
Q39ED5, LEU1_BURL3A9AJN4, LEU1_BURM1B1JVQ1, LEU1_BURO0
Q1BV03, LEU1_BURO1A3NT94, LEU1_BURP0Q3JUB9, LEU1_BURP1
A3N7K7, LEU1_BURP6Q63VP3, LEU1_BURPSA4JGE0, LEU1_BURVG
A7ZES2, LEU1_CAMC1A0RQK7, LEU1_CAMFFA7I0N8, LEU1_CAMHC
A8FP35, LEU1_CAMJ8A7H667, LEU1_CAMJDQ9PLV9, LEU1_CAMJE
A1W1X2, LEU1_CAMJJQ5HS76, LEU1_CAMJRQ3AEQ5, LEU1_CARHZ
C7QJN7, LEU1_CATADB0T0G9, LEU1_CAUSKQ9A823, LEU1_CAUVC
B8H607, LEU1_CAUVNQ7P0H2, LEU1_CHRVOA8ALM5, LEU1_CITK8
A5CRB9, LEU1_CLAM3B0RCQ8, LEU1_CLAMSQ97MC5, LEU1_CLOAB
B9E371, LEU1_CLOK1A5MZ76, LEU1_CLOK5Q8FU05, LEU1_COREF
A4QAP0, LEU1_CORGBP42455, LEU1_CORGLB1WQQ4, LEU1_CROS5
A7MIC5, LEU1_CROS8Q1LPX2, LEU1_CUPMCQ0KCT8, LEU1_CUPNH
Q473V1, LEU1_CUPPJB2AHM5, LEU1_CUPTRP85362, LEU1_CYCRE
Q47BI0, LEU1_DECARQ9RUA9, LEU1_DEIRAB1I1Y1, LEU1_DESAP
Q24PE3, LEU1_DESHYA4J181, LEU1_DESRMB8DM91, LEU1_DESVM
B5YEF4, LEU1_DICT6B8E2W9, LEU1_DICTDA7ZHG6, LEU1_ECO24
B7UIC4, LEU1_ECO27B7MAJ9, LEU1_ECO45B7LFU5, LEU1_ECO55
Q8X9Z8, LEU1_ECO57B5YZB0, LEU1_ECO5EB7NHI2, LEU1_ECO7I
B7MNT2, LEU1_ECO81B7M119, LEU1_ECO8AC4ZPZ7, LEU1_ECOBW
A7ZW25, LEU1_ECOHSA1A7C2, LEU1_ECOK1Q0TLR5, LEU1_ECOL5
Q8FL75, LEU1_ECOL6B1IRA4, LEU1_ECOLCP09151, LEU1_ECOLI
B7N7U9, LEU1_ECOLUB6HZ24, LEU1_ECOSEB1LG11, LEU1_ECOSM
Q1RGC3, LEU1_ECOUTC5B7R4, LEU1_EDWI9B1H0A7, LEU1_ENDTX
A4W6H9, LEU1_ENT38B2VDA7, LEU1_ERWT9B7LWE2, LEU1_ESCF3
A8L551, LEU1_FRASNQ5KWJ3, LEU1_GEOKAD3EBC1, LEU1_GEOS4
Q8RL85, LEU1_GEOSEC5D5M0, LEU1_GEOSWA4IRH8, LEU1_GEOTN
B7KJX8, LEU1_GLOC7Q7NI93, LEU1_GLOVIQ4QLS4, LEU1_HAEI8
A5UD85, LEU1_HAEIEP43861, LEU1_HAEINQ0I2G1, LEU1_HAES1
Q9K8E8, LEU1_HALH5B8CX21, LEU1_HALOHQ7VH30, LEU1_HELHP
B0TCR1, LEU1_HELMID8J0Q1, LEU1_HERSSB0USF6, LEU1_HISS2
Q31I16, LEU1_HYDCUA8AB61, LEU1_IGNH4A6WDF2, LEU1_KINRD
B5Y1W2, LEU1_KLEP3A6T4L9, LEU1_KLEP7B2GHT7, LEU1_KOCRD
Q02141, LEU1_LACLAQ02YX5, LEU1_LACLSQ6AED3, LEU1_LEIXX
B1XYA8, LEU1_LEPCPQ72RL9, LEU1_LEPICQ92A28, LEU1_LISIN
C1KWT1, LEU1_LISMCQ71Y35, LEU1_LISMFB8DBU4, LEU1_LISMH
Q8Y5R9, LEU1_LISMOA0AK92, LEU1_LISW6B1HR98, LEU1_LYSSC
A0LBW3, LEU1_MAGMMA6VSA9, LEU1_MARMSQ8THA5, LEU1_METAC
Q605K7, LEU1_METCAB3DX88, LEU1_METI4Q58595, LEU1_METJA
Q8TYB1, LEU1_METKAP58968, LEU1_METMAB8IHS8, LEU1_METNO
B1ZDN3, LEU1_METPBA2SHL8, LEU1_METPPO27525, LEU1_METTH
P94907, LEU1_MICAEB0JGK2, LEU1_MICANQ7TVV6, LEU1_MYCBO
Q9CB76, LEU1_MYCLEP9WQB2, LEU1_MYCTOP9WQB3, LEU1_MYCTU
A0PVE6, LEU1_MYCUAQ5F8D4, LEU1_NEIG1Q9JUK6, LEU1_NEIMA
Q9JZG1, LEU1_NEIMBA1KTV6, LEU1_NEIMFQ0AGN5, LEU1_NITEC
Q820M0, LEU1_NITEUQ1QJV3, LEU1_NITHXQ2YBW0, LEU1_NITMU
Q3J877, LEU1_NITOCA6Q4V5, LEU1_NITSBQ3SQ49, LEU1_NITWN
Q5YVA5, LEU1_NOCFAP48575, LEU1_NOSS1Q8EN67, LEU1_OCEIH
E1QWZ1, LEU1_OLSUVA1R6V4, LEU1_PAEATA6LDN1, LEU1_PARD8
A7HP03, LEU1_PARL1Q7U892, LEU1_PARMWB2JDN6, LEU1_PARP8
B2SXZ9, LEU1_PARPJQ13WM0, LEU1_PARXLQ9CJN5, LEU1_PASMU
Q6D0G8, LEU1_PECASC6DEV8, LEU1_PECCPA5D4W0, LEU1_PELTS
Q7N129, LEU1_PHOLLQ6LV24, LEU1_PHOPRA4SXR0, LEU1_POLAQ
A1VN06, LEU1_POLNAB1XUJ3, LEU1_POLNSQ12B47, LEU1_POLSJ
A3PDH0, LEU1_PROM0A2C3L7, LEU1_PROM1A8G5D5, LEU1_PROM2
A2C859, LEU1_PROM3A9BB43, LEU1_PROM4A2BX52, LEU1_PROM5
Q31AF9, LEU1_PROM9Q7VBG1, LEU1_PROMAB4F194, LEU1_PROMH
Q7TUV5, LEU1_PROMMQ7V121, LEU1_PROMPA2BRP4, LEU1_PROMS
Q46K01, LEU1_PROMTQ48LY5, LEU1_PSE14Q15QR4, LEU1_PSEA6
A6V0X2, LEU1_PSEA7Q9HXK5, LEU1_PSEAEB8H8Q9, LEU1_PSECP
Q1I5K2, LEU1_PSEE4Q4K6V7, LEU1_PSEF5C3K1K7, LEU1_PSEFS
A4XY24, LEU1_PSEMYA5VZB6, LEU1_PSEP1Q3K7C3, LEU1_PSEPF
B0KRD9, LEU1_PSEPGQ88P28, LEU1_PSEPKB1JDI2, LEU1_PSEPW
Q886Y1, LEU1_PSESMQ4ZX14, LEU1_PSEU2A4VNV6, LEU1_PSEU5
A1SRG8, LEU1_PSYINQ9UZ08, LEU1_PYRABQ8ZW35, LEU1_PYRAE
Q8U2A2, LEU1_PYRFUB2UJY9, LEU1_RALPJQ8XXP1, LEU1_RALSO
A9WML8, LEU1_RENSMQ1MDH6, LEU1_RHIL3Q98HN3, LEU1_RHILO
Q9X7L2, LEU1_RHIMEQ7UI51, LEU1_RHOBAQ2IUT4, LEU1_RHOP2
Q07PI3, LEU1_RHOP5Q6N858, LEU1_RHOPAQ212A9, LEU1_RHOPB
Q138Z2, LEU1_RHOPSB3QCX5, LEU1_RHOPTQ2RT17, LEU1_RHORT
B7JYP4, LEU1_RIPO1B8I1T7, LEU1_RUMCHA1AWA1, LEU1_RUTMC
Q97W36, LEU1_SACS2B5F7U9, LEU1_SALA4A9MQD8, LEU1_SALAR
Q57TE6, LEU1_SALCHB5FI58, LEU1_SALDCB5R2K9, LEU1_SALEP
B5RGE4, LEU1_SALG2B4TJ72, LEU1_SALHSB4SU36, LEU1_SALNS
Q5PDG1, LEU1_SALPAA9MZK0, LEU1_SALPBC0Q5H1, LEU1_SALPC
B5BLB5, LEU1_SALPKD5HB86, LEU1_SALRMB4TWW1, LEU1_SALSV
Q8Z9I0, LEU1_SALTIP15875, LEU1_SALTYO59736, LEU1_SCHPO
E1R5X1, LEU1_SEDSSA8G9R1, LEU1_SERP5A1S2E0, LEU1_SHEAM
B8E4K4, LEU1_SHEB2A3CZK5, LEU1_SHEB5A6WIB5, LEU1_SHEB8
A9KY13, LEU1_SHEB9Q12SE7, LEU1_SHEDOQ07WG9, LEU1_SHEFN
B0TQM0, LEU1_SHEHHA3QIP0, LEU1_SHELPQ8E9N2, LEU1_SHEON
A8H9A1, LEU1_SHEPAA4Y2M0, LEU1_SHEPCB8CM39, LEU1_SHEPW
A0L1R0, LEU1_SHESAA8FQ83, LEU1_SHESHQ0HE65, LEU1_SHESM
Q0HZT4, LEU1_SHESRA1REY0, LEU1_SHESWB1KKZ4, LEU1_SHEWM
B2U281, LEU1_SHIB3Q326G1, LEU1_SHIBSQ32K20, LEU1_SHIDS
Q0T8C4, LEU1_SHIF8Q83SP0, LEU1_SHIFLQ3Z5T6, LEU1_SHISS
Q2NVW3, LEU1_SODGMC4XPA8, LEU1_SOLM1Q39891, LEU1_SOYBN
A7X4N1, LEU1_STAA1A6U3E2, LEU1_STAA2Q2FF67, LEU1_STAA3
Q2FWK3, LEU1_STAA8A5IUK3, LEU1_STAA9Q2YUF2, LEU1_STAAB
Q5HEE4, LEU1_STAACA6QIQ3, LEU1_STAAEP63476, LEU1_STAAM
P63477, LEU1_STAANQ6GF16, LEU1_STAARQ6G7Q1, LEU1_STAAS
A8Z4W0, LEU1_STAATP58899, LEU1_STAAWB9DMJ6, LEU1_STACT
Q5HMF9, LEU1_STAEQQ8CNL3, LEU1_STAESQ4L7U0, LEU1_STAHJ
Q49Z12, LEU1_STAS1Q82BV3, LEU1_STRAWO31046, LEU1_STRCO
D3HCJ2, LEU1_STRG3B4SI67, LEU1_STRM5B2FT78, LEU1_STRMK
D2ATJ4, LEU1_STRRDQ4JA78, LEU1_SULACQ974X3, LEU1_SULTO
Q2LWJ3, LEU1_SYNASB1XLQ9, LEU1_SYNP2A5GM47, LEU1_SYNPW
A5GRZ0, LEU1_SYNR3Q0IBI3, LEU1_SYNS3Q3AYY2, LEU1_SYNS9
Q3AIA2, LEU1_SYNSCP48576, LEU1_SYNY3Q47RM9, LEU1_THEFY
Q9WZ23, LEU1_THEMAB9KB95, LEU1_THENNA5IJM2, LEU1_THEP1
B1L8U2, LEU1_THESQQ56216, LEU1_THETHQ8DJ32, LEU1_THEVB
Q3SHE7, LEU1_THIDAC4LAV7, LEU1_TOLATQ112U2, LEU1_TRIEI
Q3MBA3, LEU1_TRIV2C5CYP2, LEU1_VARPSA1WNY5, LEU1_VEREI
A5CWZ3, LEU1_VESOHB7VIF2, LEU1_VIBA3Q9KP83, LEU1_VIBCH
C3LR32, LEU1_VIBCMQ87SS7, LEU1_VIBPAQ8DEE1, LEU1_VIBVU
Q7MP77, LEU1_VIBVYQ7M9W4, LEU1_WOLSUP58900, LEU1_XANAC
Q3BPJ9, LEU1_XANC5Q4UYG1, LEU1_XANC8B0RP28, LEU1_XANCB
P58901, LEU1_XANCPQ2P761, LEU1_XANOMB2SNG9, LEU1_XANOP
Q5H4C6, LEU1_XANORB2I596, LEU1_XYLF2Q9PCG3, LEU1_XYLFA
Q87CL8, LEU1_XYLFTP06208, LEU1_YEASTA1JJH7, LEU1_YERE8
A7FM84, LEU1_YERP3Q1C1Z6, LEU1_YERPAB2K4C9, LEU1_YERPB
Q8ZIG8, LEU1_YERPEA9R142, LEU1_YERPGQ1CMP5, LEU1_YERPN
A4TQA2, LEU1_YERPPQ66EM1, LEU1_YERPSB1JK98, LEU1_YERPY
Q12166, LEU9_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-