Expasy logo

ENZYME

ENZYME entry: EC 2.3.3.17

PURL: https://purl.expasy.org/enzyme/EC/2.3.3.17
Accepted Name
methylthioalkylmalate synthase
Reaction catalysed
an omega-(methylsulfanyl)-2-oxoalkanoate + acetyl-CoA + H2O = a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)
Comment(s)
  • The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates.
  • Two forms are known - MAM1 catalyzes only only the first two rounds of methionine chain elongation, while MAM3 catalyzes all six cycles, up to formation of L-hexahomomethionine.
Cross-references
BRENDA2.3.3.17
EC2PDB2.3.3.17
ExplorEnz2.3.3.17
KEGG Ligand Database for Enzyme Nomenclature2.3.3.17
IUBMB Enzyme Nomenclature2.3.3.17
MEDLINEFind literature relating to 2.3.3.17
MetaCyc2.3.3.17
Rhea expert-curated reactions2.3.3.17
UniProtKB/Swiss-Prot
P0DO77, MAM11_EUTJAP0DO78, MAM12_EUTJAQ9FG67, MAM1_ARATH
Q8VX04, MAM2_ARATHQ9FN52, MAM3_ARATH

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-