ID   2.3.3.21
DE   (R)-citramalate synthase.
CA   acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+).
CC   -!- One of the enzymes involved in a pyruvate-derived pathway for
CC       isoleucine biosynthesis that is found in some bacterial and archaeal
CC       species.
CC   -!- The enzyme can be inhibited by isoleucine, the end-product of the
CC       pathway, but not by leucine.
CC   -!- The enzyme is highly specific for pyruvate as substrate, as the 2-oxo
CC       acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2-
CC       oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as
CC       substrate.
CC   -!- Formerly EC 2.3.1.182.
DR   O66682, CIMA_AQUAE ;  O29305, CIMA_ARCFU ;  Q74C76, CIMA_GEOSL ;
DR   Q8F3Q1, CIMA_LEPIN ;  Q8TJJ1, CIMA_METAC ;  Q58787, CIMA_METJA ;
DR   Q8TYM1, CIMA_METKA ;  P58966, CIMA_METMA ;  A3CUF2, CIMA_METMJ ;
DR   B8GEI1, CIMA_METPE ;  O26819, CIMA_METTH ;  O86511, CIMA_STRCO ;
DR   Q4J6H1, CIMA_SULAC ;  P74269, CIMA_SYNY3 ;  Q9WZ22, CIMA_THEMA ;
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