ENZYME entry: EC 2.3.3.9

Accepted Name

malate synthase

Alternative Name(s)

glyoxylate transacetase

glyoxylate transacetylase

glyoxylic transacetase

L-malate glyoxylate-lyase (CoA-acetylating)

malate condensing enzyme

malate synthetase

malic-condensing enzyme

malic synthetase

Reaction catalysed

acetyl-CoA + glyoxylate + H2O <=> (S)-malate + CoA + H(+)

Comment(s)

The enzyme catalyzes the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate.
Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO2.
Formerly EC 4.1.3.2.

Cross-references

BRENDA

2.3.3.9

EC2PDB

2.3.3.9

ExplorEnz

2.3.3.9

PRIAM enzyme-specific profiles

2.3.3.9

KEGG Ligand Database for Enzyme Nomenclature

2.3.3.9

IUBMB Enzyme Nomenclature

2.3.3.9

IntEnz

2.3.3.9

MEDLINE

Find literature relating to 2.3.3.9

MetaCyc

2.3.3.9

Rhea expert-curated reactions

2.3.3.9

UniProtKB/Swiss-Prot

D4GTL2, ACEB_HALVD	Q8N0X4, CLYBL_HUMAN	Q8R4N0, CLYBL_MOUSE
Q5I0K3, CLYBL_RAT	Q10663, GCP_CAEEL	Q9LZC3, MASY_ARATH
P13244, MASY_BRANA	Q02216, MASY_CANTR	P24571, MASY_CUCMA
P08216, MASY_CUCSA	Q8T2K9, MASY_DICDI	P08997, MASY_ECOLI
P28344, MASY_EMENI	P17432, MASY_GOSHI	P49081, MASY_MAIZE
P95329, MASY_MYXXD	P28345, MASY_NEUCR	Q7XUG1, MASY_ORYSJ
P21360, MASY_PICAN	Q43827, MASY_RAPSA	P17815, MASY_RICCO
P45458, MASY_SOYBN	P77947, MASY_STRAE	Q9ZH77, MASY_STRCL
Q88AB2, MASZ1_PSESM	Q87Z72, MASZ2_PSESM	Q8UJ85, MASZ_AGRFC
B9JG75, MASZ_AGRRK	B9JXY6, MASZ_AGRVS	Q0A845, MASZ_ALKEH
Q5P811, MASZ_AROAE	Q7WR61, MASZ_BORBR	Q7W294, MASZ_BORPA
A9IHH4, MASZ_BORPD	Q7VT71, MASZ_BORPE	Q89UE3, MASZ_BRADU
A4YM47, MASZ_BRASO	B2S793, MASZ_BRUA1	Q2YRK5, MASZ_BRUA2
A6WYD2, MASZ_BRUA4	Q57BM8, MASZ_BRUAB	A9M752, MASZ_BRUC2
C0RES0, MASZ_BRUMB	Q8YIR3, MASZ_BRUME	A5VS09, MASZ_BRUO2
A9WWC9, MASZ_BRUSI	Q8FZ50, MASZ_BRUSU	Q11BE3, MASZ_CHESB
Q1QSR0, MASZ_CHRSD	Q8FNB3, MASZ_COREF	P42450, MASZ_CORGL
A9BRF0, MASZ_DELAS	Q8FDN6, MASZ_ECOL6	P37330, MASZ_ECOLI
Q5KZR8, MASZ_GEOKA	C5D2K6, MASZ_GEOSW	A4IN50, MASZ_GEOTN
Q9KB03, MASZ_HALH5	A1U1Q6, MASZ_MARN8	A0QGM8, MASZ_MYCA1
B1MB69, MASZ_MYCA9	P0A5J5, MASZ_MYCBO	A1KJP9, MASZ_MYCBP
C1APB4, MASZ_MYCBT	A4TAC4, MASZ_MYCGI	B8ZSN3, MASZ_MYCLB
O32913, MASZ_MYCLE	B2HSY2, MASZ_MYCMM	Q73ZQ2, MASZ_MYCPA
A3Q0E7, MASZ_MYCSJ	A1UGU7, MASZ_MYCSK	Q1B860, MASZ_MYCSS
A5U3K4, MASZ_MYCTA	P9WK16, MASZ_MYCTO	P9WK17, MASZ_MYCTU
A0PSI5, MASZ_MYCUA	A1T9P9, MASZ_MYCVP	Q1QHK3, MASZ_NITHX
Q3SNX3, MASZ_NITWN	Q5YWU1, MASZ_NOCFA	Q13YU3, MASZ_PARXL
A6UYU5, MASZ_PSEA7	B7V467, MASZ_PSEA8	Q02TT1, MASZ_PSEAB
Q9I636, MASZ_PSEAE	Q4K4S5, MASZ_PSEF5	O05137, MASZ_PSEFL
Q3K5N4, MASZ_PSEPF	Q88QX8, MASZ_PSEPK	B3PWJ0, MASZ_RHIE6
Q2KE51, MASZ_RHIEC	Q1MNB0, MASZ_RHIL3	Q98DK4, MASZ_RHILO
Q937W7, MASZ_RHILV	B5ZVA2, MASZ_RHILW	Q92TA4, MASZ_RHIME
C0ZZZ0, MASZ_RHOE4	Q9AE55, MASZ_RHOFA	Q2J0A5, MASZ_RHOP2
Q6N234, MASZ_RHOPA	Q13BC6, MASZ_RHOPS	B3QKU1, MASZ_RHOPT
P59663, MASZ_SHIFL	C3MBD2, MASZ_SINFN	A6UEL4, MASZ_SINMW
C5CJB5, MASZ_VARPS	A6ZRW6, MLS1_YEAS7	P30952, MLS1_YEAST
P21826, MLS2_YEAST

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