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ENZYME entry: EC 2.4.1.102

Accepted Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N- acetylglucosaminyltransferase.
Alternative Name(s)
beta6-N-acetylglucosaminyltransferase.
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I.
Reaction catalysed
  • O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP
  • O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP
Comment(s)
The enzyme catalyzes the addition of N-acetyl-alpha-D-glucosamine to the core 1 structure of O-glycans forming core 2.
Cross-references
BRENDA2.4.1.102
EC2PDB2.4.1.102
ExplorEnz2.4.1.102
PRIAM enzyme-specific profiles2.4.1.102
KEGG Ligand Database for Enzyme Nomenclature2.4.1.102
IUBMB Enzyme Nomenclature2.4.1.102
IntEnz2.4.1.102
MEDLINEFind literature relating to 2.4.1.102
MetaCyc2.4.1.102
Rhea expert-curated reactions2.4.1.102
UniProtKB/Swiss-Prot
Q92180, GCNT1_BOVIN;  Q02742, GCNT1_HUMAN;  Q09324, GCNT1_MOUSE;  
Q80RC7, GCNT3_BHV4;  Q99CW3, GCNT3_BHV4D;  Q805R1, GCNT3_BHV4L;  
Q9IZK2, GCNT3_BHV4V;  Q866Z5, GCNT3_BOSMU;  Q7YQE1, GCNT3_BOVIN;  
Q1M0V6, GCNT3_BUBBU;  O95395, GCNT3_HUMAN;  Q5JCT0, GCNT3_MOUSE;  
Q8CH87, GCNT3_RAT;  Q866Z6, GCNT3_SHEEP;  Q866Z4, GCNT3_SYNCA;  
Q5U258, GCNT3_XENLA;  Q71SG7, GCNT4_DANRE;  Q9P109, GCNT4_HUMAN;  
E9Q649, GCNT4_MOUSE;  

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