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ENZYME

ENZYME entry: EC 2.4.1.102

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.102
Accepted Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N- acetylglucosaminyltransferase
Alternative Name(s)
beta6-N-acetylglucosaminyltransferase
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
Reaction catalysed
  • a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP + H(+)
  • a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = a 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP + H(+)
Comment(s)
The enzyme catalyzes the addition of N-acetyl-alpha-D-glucosamine to the core 1 structure of O-glycans forming core 2.
Cross-references
BRENDA2.4.1.102
EC2PDB2.4.1.102
ExplorEnz2.4.1.102
KEGG Ligand Database for Enzyme Nomenclature2.4.1.102
IUBMB Enzyme Nomenclature2.4.1.102
MEDLINEFind literature relating to 2.4.1.102
MetaCyc2.4.1.102
Rhea expert-curated reactions2.4.1.102
UniProtKB/Swiss-Prot
Q92180, GCNT1_BOVINQ02742, GCNT1_HUMANQ09324, GCNT1_MOUSE
Q80RC7, GCNT3_BHV4Q99CW3, GCNT3_BHV4DQ805R1, GCNT3_BHV4L
Q9IZK2, GCNT3_BHV4VQ866Z5, GCNT3_BOSMUQ7YQE1, GCNT3_BOVIN
Q1M0V6, GCNT3_BUBBUO95395, GCNT3_HUMANQ5JCT0, GCNT3_MOUSE
Q8CH87, GCNT3_RATQ866Z6, GCNT3_SHEEPQ866Z4, GCNT3_SYNCA
Q5U258, GCNT3_XENLAQ71SG7, GCNT4_DANREQ9P109, GCNT4_HUMAN
E9Q649, GCNT4_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-