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ENZYME

ENZYME entry: EC 2.4.1.109

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.109
Accepted Name
dolichyl-phosphate-mannose--protein mannosyltransferase
Alternative Name(s)
dolichol phosphomannose-protein mannosyltransferase
dolichyl-phosphate-mannose-protein mannosyltransferase
Reaction catalysed
  • a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)
  • a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)
Comment(s)
  • Transfers mannosyl residues to the hydroxy of serine or threonine residues, producing cell-wall mannoproteins.
  • Acts only on long-chain alpha-dihydropolyprenyl derivatives, larger than C35.
Cross-references
BRENDA2.4.1.109
EC2PDB2.4.1.109
ExplorEnz2.4.1.109
KEGG Ligand Database for Enzyme Nomenclature2.4.1.109
IUBMB Enzyme Nomenclature2.4.1.109
MEDLINEFind literature relating to 2.4.1.109
MetaCyc2.4.1.109
Rhea expert-curated reactions2.4.1.109
UniProtKB/Swiss-Prot
O74189, PMT1_CANALO13898, PMT1_SCHPOP33775, PMT1_YEAST
Q5ADM9, PMT2_CANALQ9C100, PMT2_SCHPOP31382, PMT2_YEAST
P47190, PMT3_YEASTQ59X23, PMT4_CANALO42933, PMT4_SCHPO
P46971, PMT4_YEASTQ5ACU3, PMT5_CANALP52867, PMT5_YEAST
Q5A688, PMT6_CANALP42934, PMT6_YEASTQ06644, PMT7_YEAST
F1QF89, POMT1_DANREQ9VTK2, POMT1_DROMEQ2LZ62, POMT1_DROPS
Q9Y6A1, POMT1_HUMANQ8R2R1, POMT1_MOUSEQ99PR0, POMT1_RAT
F1Q8R9, POMT2_DANREQ9W5D4, POMT2_DROMEQ29IL2, POMT2_DROPS
Q9UKY4, POMT2_HUMANQ8BGQ4, POMT2_MOUSEQ8MXQ3, TM260_DICDI
Q9NX78, TM260_HUMANQ8BMD6, TM260_MOUSEQ20144, TMTC1_CAEEL
Q9VQE9, TMTC1_DROMEQ8IUR5, TMTC1_HUMANQ3UV71, TMTC1_MOUSE
Q9V3X5, TMTC2_DROMEQ8N394, TMTC2_HUMANQ56A06, TMTC2_MOUSE
Q6DCD5, TMTC2_XENLAQ7K4B6, TMTC3_DROMEQ6ZXV5, TMTC3_HUMAN
Q8BRH0, TMTC3_MOUSEQ9VF81, TMTC4_DROMEQ5T4D3, TMTC4_HUMAN
Q8BG19, TMTC4_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-