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ENZYME entry: EC 2.4.1.11

Accepted Name
Glycogen(starch) synthase.
Alternative Name(s)
UDP-glucose--glycogen glucosyltransferase.
Reaction catalysed
UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) <=> UDP + ((1->4)-alpha-D-glucosyl)(n+1)
Comment(s)
  • The description (official name) varies according to the source of the enzyme and the nature of its synthetic product.
  • Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin.
  • The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186.
  • A similar enzyme utilizes ADP-glucose (cf. EC 2.4.1.21).
Cross-references
BRENDA2.4.1.11
EC2PDB2.4.1.11
ExplorEnz2.4.1.11
PRIAM enzyme-specific profiles2.4.1.11
KEGG Ligand Database for Enzyme Nomenclature2.4.1.11
IUBMB Enzyme Nomenclature2.4.1.11
IntEnz2.4.1.11
MEDLINEFind literature relating to 2.4.1.11
MetaCyc2.4.1.11
UniProtKB/Swiss-Prot
P9WMY8, GLGSY_MYCTO;  P9WMY9, GLGSY_MYCTU;  A7MB78, GYS1_BOVIN;  
P13807, GYS1_HUMAN;  Q8MJ26, GYS1_MACMU;  Q9Z1E4, GYS1_MOUSE;  
Q5R9H0, GYS1_PONAB;  P13834, GYS1_RABIT;  A2RRU1, GYS1_RAT;  
P23337, GYS1_YEAST;  P54840, GYS2_HUMAN;  Q8VCB3, GYS2_MOUSE;  
P17625, GYS2_RAT;  P27472, GYS2_YEAST;  Q9U2D9, GYS_CAEEL;  
Q55GH4, GYS_DICDI;  Q9VFC8, GYS_DROME;  O93869, GYS_NEUCR;  

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