ENZYME entry: EC 2.4.1.122
Accepted Name |
N-acetylgalactosaminide beta-1,3-galactosyltransferase.
|
Alternative Name(s) |
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase. |
Uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase. |
Reaction catalysed |
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R <=> UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R |
Comment(s) |
- The eukaryotic enzyme can act on non-reducing O-serine-linked
N-acetylgalactosamine residues in mucin glycoproteins, forming the
T-antigen.
- The bacterial enzyme, found in some pathogenic strains, is involved
in biosynthesis of the O-antigen repeating unit.
- Formerly EC 2.4.1.307.
|
Cross-references |
BRENDA | 2.4.1.122 |
EC2PDB | 2.4.1.122 |
ExplorEnz | 2.4.1.122 |
PRIAM enzyme-specific profiles | 2.4.1.122 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.122 |
IUBMB Enzyme Nomenclature | 2.4.1.122 |
IntEnz | 2.4.1.122 |
MEDLINE | Find literature relating to 2.4.1.122 |
MetaCyc | 2.4.1.122 |
Rhea expert-curated reactions | 2.4.1.122 |
UniProtKB/Swiss-Prot |
Q0VC84, C1GLT_BOVIN; | Q18515, C1GLT_CAEEL; | Q5F3G7, C1GLT_CHICK; |
Q7K237, C1GLT_DROME; | Q9NS00, C1GLT_HUMAN; | Q9JJ06, C1GLT_MOUSE; |
Q9JJ05, C1GLT_RAT; | Q6GNL1, C1GLT_XENLA; | Q08BL3, C1GTA_DANRE; |
Q7SYI5, C1GTB_DANRE; | Q4KXC9, WBNJ_ECOLX; |
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