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ENZYME entry: EC 2.4.1.122

Accepted Name
N-acetylgalactosaminide beta-1,3-galactosyltransferase.
Alternative Name(s)
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase.
Uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase.
Reaction catalysed
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R <=> UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
Comment(s)
  • The eukaryotic enzyme can act on non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins, forming the T-antigen.
  • The bacterial enzyme, found in some pathogenic strains, is involved in biosynthesis of the O-antigen repeating unit.
  • Formerly EC 2.4.1.307.
Cross-references
BRENDA2.4.1.122
EC2PDB2.4.1.122
ExplorEnz2.4.1.122
PRIAM enzyme-specific profiles2.4.1.122
KEGG Ligand Database for Enzyme Nomenclature2.4.1.122
IUBMB Enzyme Nomenclature2.4.1.122
IntEnz2.4.1.122
MEDLINEFind literature relating to 2.4.1.122
MetaCyc2.4.1.122
Rhea expert-curated reactions2.4.1.122
UniProtKB/Swiss-Prot
Q0VC84, C1GLT_BOVIN;  Q18515, C1GLT_CAEEL;  Q5F3G7, C1GLT_CHICK;  
Q7K237, C1GLT_DROME;  Q9NS00, C1GLT_HUMAN;  Q9JJ06, C1GLT_MOUSE;  
Q9JJ05, C1GLT_RAT;  Q6GNL1, C1GLT_XENLA;  Q08BL3, C1GTA_DANRE;  
Q7SYI5, C1GTB_DANRE;  Q4KXC9, WBNJ_ECOLX;  

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