ENZYME entry: EC 2.4.1.125
| Accepted Name |
|---|
| Sucrose--1,6-alpha-glucan 3(6)-alpha-glucosyltransferase.
|
| Alternative Name(s) |
|---|
| Water-soluble-glucan synthase. |
| Reaction catalysed |
|---|
- Sucrose + ((1->6)-alpha-D-glucosyl)(n) <=> D-fructose + ((1->6)-alpha-D-glucosyl)(n+1)
- Sucrose + ((1->6)-alpha-D-glucosyl)(n) <=> D-fructose + (1->3)-alpha-D-glucosyl-((1->6)-alpha-D-glucosyl)(n)
|
| Comment(s) |
|---|
- The enzyme was characterized from the dental caries bacterium
Streptococcus mutans.
- It transfers glucosyl residues from sucrose to either the 6- or the
3-positions of glucose residues in glucans, producing a highly-
branched extracellular D-glucan polymers that promote attachment of
the bacteria to teeth.
- Three types of the enzyme have been described; the insoluble polymers
produced by GTF-I and GTF-SI contain 85% alpha(1->3) bonds and 15%
alpha(1->6) bonds, while the soluble polymers produced by GTF-S
contain only 30% of alpha(1->3) bonds and 70% alpha(1->6) bonds.
- Cf. EC 2.4.1.5.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.125 |
| EC2PDB | 2.4.1.125 |
| ExplorEnz | 2.4.1.125 |
| PRIAM enzyme-specific profiles | 2.4.1.125 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.125 |
| IUBMB Enzyme Nomenclature | 2.4.1.125 |
| IntEnz | 2.4.1.125 |
| MEDLINE | Find literature relating to 2.4.1.125 |
| MetaCyc | 2.4.1.125 |
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