ENZYME entry: EC 2.4.1.135
| Accepted Name |
|---|
| Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase.
|
| Alternative Name(s) |
|---|
| Glucuronosyltransferase I. |
| Uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase. |
| Reaction catalysed |
|---|
| UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine <=> UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine |
| Cofactor(s) |
|---|
| Mn(2+).
|
| Comment(s) |
|---|
| Involved in the biosynthesis of the linkage region of
glycosaminoglycan chains as part of proteoglycan biosynthesis
(chondroitin, dermatan and heparan sulfates).
|
| Cross-references |
|---|
| BRENDA | 2.4.1.135 |
| EC2PDB | 2.4.1.135 |
| ExplorEnz | 2.4.1.135 |
| PRIAM enzyme-specific profiles | 2.4.1.135 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.135 |
| IUBMB Enzyme Nomenclature | 2.4.1.135 |
| IntEnz | 2.4.1.135 |
| MEDLINE | Find literature relating to 2.4.1.135 |
| MetaCyc | 2.4.1.135 |
| Rhea expert-curated reactions | 2.4.1.135 |
| UniProtKB/Swiss-Prot |
| Q9VTG7, B3G2P_DROME; | Q9VLA1, B3G2S_DROME; | Q5CB03, B3GA1_CANLF; |
| Q9P2W7, B3GA1_HUMAN; | Q9CW73, B3GA1_MOUSE; | Q5CB04, B3GA1_PANTR; |
| O35789, B3GA1_RAT; | Q5CAZ6, B3GA2_CANLF; | Q9NPZ5, B3GA2_HUMAN; |
| P59270, B3GA2_MOUSE; | Q9Z137, B3GA2_RAT; | Q9WU47, B3GA3_CRIGR; |
| O94766, B3GA3_HUMAN; | P58158, B3GA3_MOUSE; | O97422, B3GI_DROME; |
| Q09363, SQV8_CAEEL; |
|
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UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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