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ENZYME entry: EC 2.4.1.14

Accepted Name
Sucrose-phosphate synthase.
Alternative Name(s)
Sucrosephosphate--UDP glucosyltransferase.
UDP-glucose-fructose-phosphate glucosyltransferase.
Reaction catalysed
UDP-glucose + D-fructose 6-phosphate <=> UDP + sucrose 6(F)-phosphate
Cofactor(s)
Mn(2+) or Mg(2+).
Comment(s)
  • The enzyme from Synechocystis sp. strain PCC 6803 is not specific for UDP-glucose as it can use ADP-glucose and, to a lesser extent, GDP- glucose as substrates.
  • The enzyme from rice leaves is activated by glucose 6-phosphate but that from cyanobacterial species is not.
  • While the reaction catalyzed by this enzyme is reversible, the enzyme usually works in concert with EC 3.1.3.24 to form sucrose, making the above reaction essentially irreversible.
  • The F in sucrose 6(F)-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.
Cross-references
BRENDA2.4.1.14
EC2PDB2.4.1.14
ExplorEnz2.4.1.14
PRIAM enzyme-specific profiles2.4.1.14
KEGG Ligand Database for Enzyme Nomenclature2.4.1.14
IUBMB Enzyme Nomenclature2.4.1.14
IntEnz2.4.1.14
MEDLINEFind literature relating to 2.4.1.14
MetaCyc2.4.1.14
Rhea expert-curated reactions2.4.1.14
UniProtKB/Swiss-Prot
Q94BT0, SPSA1_ARATH;  O22060, SPSA1_CITUN;  O04932, SPSA1_CRAPL;  
A2WYE9, SPSA1_ORYSI;  Q0JGK4, SPSA1_ORYSJ;  Q9FY54, SPSA2_ARATH;  
O04933, SPSA2_CRAPL;  B7F7B9, SPSA2_ORYSJ;  Q8RY24, SPSA3_ARATH;  
Q67WN8, SPSA3_ORYSJ;  F4JLK2, SPSA4_ARATH;  Q6ZHZ1, SPSA4_ORYSJ;  
Q53JI9, SPSA5_ORYSJ;  P49031, SPSA_BETVU;  P31927, SPSA_MAIZE;  
Q43845, SPSA_SOLTU;  P31928, SPSA_SPIOL;  Q43876, SPSA_VICFA;  
A6LKE9, SPS_THEM4;  

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