ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.1.14

Accepted Name

Sucrose-phosphate synthase.

Alternative Name(s)

Sucrosephosphate--UDP glucosyltransferase.

UDP-glucose-fructose-phosphate glucosyltransferase.

Reaction catalysed

UDP-glucose + D-fructose 6-phosphate <=> UDP + sucrose 6(F)-phosphate

Cofactor(s)

Mn(2+) or Mg(2+).

Comment(s)

The enzyme from Synechocystis sp. strain PCC 6803 is not specific for UDP-glucose as it can use ADP-glucose and, to a lesser extent, GDP- glucose as substrates.
The enzyme from rice leaves is activated by glucose 6-phosphate but that from cyanobacterial species is not.
While the reaction catalyzed by this enzyme is reversible, the enzyme usually works in concert with EC 3.1.3.24 to form sucrose, making the above reaction essentially irreversible.
The F in sucrose 6(F)-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

UniProtKB/Swiss-Prot

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