Expasy logo

ENZYME

ENZYME entry: EC 2.4.1.145

Accepted Name
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Alternative Name(s)
alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase
beta-acetylglucosaminyltransferase IV
GnTIV
N-acetylglucosaminyltransferase IV
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV
uridine diphosphoacetylglucosamine-glycopeptide beta4- acetylglucosaminyltransferase IV
Reaction catalysed
N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
Comment(s)
  • The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus.
  • By adding a glucosaminyl residue to biantennary N-linked glycans, it enables the synthesis of tri- and tetra-antennary complexes.
  • Formerly EC 2.4.1.51.
Cross-references
BRENDA2.4.1.145
EC2PDB2.4.1.145
ExplorEnz2.4.1.145
PRIAM enzyme-specific profiles2.4.1.145
KEGG Ligand Database for Enzyme Nomenclature2.4.1.145
IUBMB Enzyme Nomenclature2.4.1.145
IntEnz2.4.1.145
MEDLINEFind literature relating to 2.4.1.145
MetaCyc2.4.1.145
Rhea expert-curated reactions2.4.1.145
UniProtKB/Swiss-Prot
O77836, MGT4A_BOVINQ5F407, MGT4A_CHICKQ9UM21, MGT4A_HUMAN
Q4R854, MGT4A_MACFAQ812G0, MGT4A_MOUSEQ5REP8, MGT4A_PONAB
Q5M854, MGT4A_RATQ6GQI7, MGT4A_XENLAA4IID1, MGT4A_XENTR
Q6GMK0, MGT4B_DANREQ9UQ53, MGT4B_HUMANQ812F8, MGT4B_MOUSE
Q5U3T0, MGT4C_DANREQ9UBM8, MGT4C_HUMANQ4R4A8, MGT4C_MACFA
Q9D306, MGT4C_MOUSEQ6ITT3, MGT4C_PIG

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-