| Accepted Name |
|---|
| alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase.
|
| Alternative Name(s) |
|---|
| alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase. |
| beta-acetylglucosaminyltransferase IV. |
| GnTIV. |
| N-acetylglucosaminyltransferase IV. |
| N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase
IV. |
| uridine diphosphoacetylglucosamine-glycopeptide beta4-
acetylglucosaminyltransferase IV. |
| Reaction catalysed |
|---|
| N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP |
| Comment(s) |
|---|
- The enzyme, found in vertebrates, participates in the processing of
N-glycans in the Golgi apparatus.
- By adding a glucosaminyl residue to biantennary N-linked glycans,
it enables the synthesis of tri- and tetra-antennary complexes.
- Formerly EC 2.4.1.51.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.145 |
| EC2PDB | 2.4.1.145 |
| ExplorEnz | 2.4.1.145 |
| PRIAM enzyme-specific profiles | 2.4.1.145 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.145 |
| IUBMB Enzyme Nomenclature | 2.4.1.145 |
| IntEnz | 2.4.1.145 |
| MEDLINE | Find literature relating to 2.4.1.145 |
| MetaCyc | 2.4.1.145 |
| Rhea expert-curated reactions | 2.4.1.145 |
| UniProtKB/Swiss-Prot |
| O77836, MGT4A_BOVIN; | Q5F407, MGT4A_CHICK; | Q9UM21, MGT4A_HUMAN; |
| Q4R854, MGT4A_MACFA; | Q812G0, MGT4A_MOUSE; | Q5REP8, MGT4A_PONAB; |
| Q5M854, MGT4A_RAT; | Q6GQI7, MGT4A_XENLA; | A4IID1, MGT4A_XENTR; |
| Q6GMK0, MGT4B_DANRE; | Q9UQ53, MGT4B_HUMAN; | Q812F8, MGT4B_MOUSE; |
| Q5U3T0, MGT4C_DANRE; | Q9UBM8, MGT4C_HUMAN; | Q4R4A8, MGT4C_MACFA; |
| Q9D306, MGT4C_MOUSE; | Q6ITT3, MGT4C_PIG; |
|