ENZYME entry: EC 2.4.1.145

Accepted Name

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Alternative Name(s)

alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase

beta-acetylglucosaminyltransferase IV

GnTIV

N-acetylglucosaminyltransferase IV

N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV

uridine diphosphoacetylglucosamine-glycopeptide beta4- acetylglucosaminyltransferase IV

Reaction catalysed

N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP

Comment(s)

The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus.
By adding a glucosaminyl residue to biantennary N-linked glycans, it enables the synthesis of tri- and tetra-antennary complexes.
Formerly EC 2.4.1.51.

Cross-references

BRENDA

2.4.1.145

EC2PDB

2.4.1.145

ExplorEnz

2.4.1.145

PRIAM enzyme-specific profiles

2.4.1.145

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.145

IUBMB Enzyme Nomenclature

2.4.1.145

IntEnz

2.4.1.145

MEDLINE

Find literature relating to 2.4.1.145

MetaCyc

2.4.1.145

Rhea expert-curated reactions

2.4.1.145

UniProtKB/Swiss-Prot

O77836, MGT4A_BOVIN	Q5F407, MGT4A_CHICK	Q9UM21, MGT4A_HUMAN
Q4R854, MGT4A_MACFA	Q812G0, MGT4A_MOUSE	Q5REP8, MGT4A_PONAB
Q5M854, MGT4A_RAT	Q6GQI7, MGT4A_XENLA	A4IID1, MGT4A_XENTR
Q6GMK0, MGT4B_DANRE	Q9UQ53, MGT4B_HUMAN	Q812F8, MGT4B_MOUSE
Q5U3T0, MGT4C_DANRE	Q9UBM8, MGT4C_HUMAN	Q4R4A8, MGT4C_MACFA
Q9D306, MGT4C_MOUSE	Q6ITT3, MGT4C_PIG

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-