A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.4.1.145
Accepted Name |
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase.
|
Alternative Name(s) |
Alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase. |
Beta-acetylglucosaminyltransferase IV. |
GnTIV. |
N-acetylglucosaminyltransferase IV. |
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase
IV. |
Uridine diphosphoacetylglucosamine-glycopeptide beta-4-
acetylglucosaminyltransferase IV. |
Reaction catalysed |
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-(beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] <=> UDP + beta-D-GlcNAc-(1->2)-(beta-D-GlcNAc-(1->4))-alpha-D-Man-(1->3)-(beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] |
Comment(s) |
- The enzyme, found in vertebrates, participates in the processing of
N-glycans in the Golgi apparatus.
- By adding a glucosaminyl residue to biantennary N-linked glycans,
it enables the synthesis of tri- and tetra-antennary complexes.
- Formerly EC 2.4.1.51.
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Cross-references |
BRENDA | 2.4.1.145 |
EC2PDB | 2.4.1.145 |
ExplorEnz | 2.4.1.145 |
PRIAM enzyme-specific profiles | 2.4.1.145 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.145 |
IUBMB Enzyme Nomenclature | 2.4.1.145 |
IntEnz | 2.4.1.145 |
MEDLINE | Find literature relating to 2.4.1.145 |
MetaCyc | 2.4.1.145 |
UniProtKB/Swiss-Prot |
O77836, MGT4A_BOVIN; | Q5F407, MGT4A_CHICK; | Q9UM21, MGT4A_HUMAN; |
Q4R854, MGT4A_MACFA; | Q812G0, MGT4A_MOUSE; | Q5REP8, MGT4A_PONAB; |
Q5M854, MGT4A_RAT; | Q6GQI7, MGT4A_XENLA; | A4IID1, MGT4A_XENTR; |
Q6GMK0, MGT4B_DANRE; | Q9UQ53, MGT4B_HUMAN; | Q812F8, MGT4B_MOUSE; |
Q5U3T0, MGT4C_DANRE; | Q9UBM8, MGT4C_HUMAN; | Q4R4A8, MGT4C_MACFA; |
Q9D306, MGT4C_MOUSE; | Q6ITT3, MGT4C_PIG; |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
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