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ENZYME

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ENZYME entry: EC 2.4.1.146

Accepted Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N- acetylglucosaminyltransferase
Alternative Name(s)
elongation 3beta-GalNAc-transferase
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
Reaction catalysed
  • 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP
  • 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP
Comment(s)
The enzyme catalyzes the addition of N-acetyl-alpha-D-glucosamine to the core 2 structure of O-glycans.
Cross-references
BRENDA2.4.1.146
EC2PDB2.4.1.146
ExplorEnz2.4.1.146
PRIAM enzyme-specific profiles2.4.1.146
KEGG Ligand Database for Enzyme Nomenclature2.4.1.146
IUBMB Enzyme Nomenclature2.4.1.146
IntEnz2.4.1.146
MEDLINEFind literature relating to 2.4.1.146
MetaCyc2.4.1.146
Rhea expert-curated reactions2.4.1.146
UniProtKB/Swiss-Prot
Q9Y2A9, B3GN3_HUMANQ5JCS9, B3GN3_MOUSE

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